Drug allergy

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults with a history of possible allergic reactions using skin tests and controlled drug challenges. The goal i…

This study is testing a new blood test called the T-cell activation test to see if it can more accurately diagnose amoxicillin allergy. Researchers will compare results from 300 people with suspected allergy and those without. If the test works well, it could replace less reliabl…

This study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study looks at whether we can safely remove the "beta-lactam allergy" label from blood cancer patients who are not truly allergic. By doing so, doctors can use more effective antibiotics. The study will enroll 3,800 hospitalized adults with blood cancers and a reported aller…

This study looks at whether private practice doctors can safely give children with suspected mild delayed allergies to beta-lactam antibiotics (like amoxicillin) a direct oral challenge. The challenge involves giving the child a small dose of the antibiotic and watching for a rea…

This study tests whether a nurse and allergist working together can safely and effectively remove incorrect penicillin allergy labels from patients' records. About 440 people with a penicillin allergy label will be evaluated using this team approach or the standard allergist-only…

This study aims to understand how a type of white blood cell called eosinophils contributes to DRESS syndrome, a severe and potentially life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunte…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks back at 3,000 hospital patients to see if those who got a flu shot, took blood pressure meds (ACEI/ARB), antihistamines, or amantadine had better COVID-19 outcomes. Researchers want to know if these common treatments can reduce deaths or shorten hospital stays. N…

Stanford University is recruiting 2,500 people with possible allergies to improve how allergies are diagnosed. Researchers will study skin test responses and look at genetic and immune system factors. This study does not test any new treatment, but aims to deepen knowledge of all…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine. Researchers want to see if this new technique works as well as current tests. About 1,376 children and adults with allergies will provide blood and urine samples during routine visi…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study aims to improve how doctors choose antibiotics for patients who say they are allergic to penicillin-like drugs (beta-lactams) before orthopedic surgery. Many people think they are allergic, but only a small fraction truly are. Researchers will use a simple questionnair…

This study looks at different forms of IgE (a protein involved in allergic reactions) in healthy volunteers and people with conditions like severe allergies, chronic hives, mastocytosis, and immune deficiencies. Researchers aim to understand how these IgE variations relate to hea…

This study tests a simple computer tool that checks medical records to see if patients with a reported antibiotic allergy can safely use that antibiotic again. Many antibiotic allergy labels are incorrect, leading to use of less effective or broader-spectrum antibiotics. The tool…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…