Digestive system carcinoma
MONDO:0006181A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma.
Also known as: carcinoma of digestive system, carcinoma of the gastrointestinal system, digestive system carcinoma, gastrointestinal carcinoma, gastrointestinal carcinoma (disease), gastrointestinal system carcinoma
7516 clinical trials for this condition and its sub-types, 25 tagged with Digestive system carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system carcinoma
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Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,461 incl. sub-types
7 sub-types
- Hepatocellular carcinoma 1,046 trials · 1,091 incl. sub-types Sub-types →
- Bile duct carcinoma 20 trials · 454 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Undifferentiated carcinoma of liver and intrahepatic biliary tract 1 trial
- Biliary cystadenocarcinoma 0 trials
- Liver carcinoma in situ 0 trials Sub-types →
- Squamous cell carcinoma of liver and intrahepatic biliary tract 0 trials Sub-types →
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Colorectal carcinoma 305 trials · 1,170 incl. sub-types
4 sub-types
- Colorectal adenocarcinoma 247 trials · 548 incl. sub-types Sub-types →
- Rectal carcinoma 54 trials · 393 incl. sub-types Sub-types →
- Colon carcinoma 279 trials · 379 incl. sub-types Sub-types →
- Colorectal squamous cell carcinoma 1 trial · 54 incl. sub-types Sub-types →
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Exocrine pancreatic carcinoma 205 trials · 1,037 incl. sub-types
8 sub-types
- Pancreatic adenocarcinoma 497 trials · 930 incl. sub-types Sub-types →
- Squamous cell carcinoma of pancreas 3 trials · 13 incl. sub-types Sub-types →
- Familial pancreatic carcinoma 9 trials
- Pancreatic carcinoma with mixed differentiation 3 trials
- Pancreatic intraductal papillary-mucinous carcinoma 0 trials · 2 incl. sub-types Sub-types →
- Pancreatic mucinous cystadenoma 1 trial
- Pancreatic large cell neuroendocrine carcinoma 0 trials
- Solid pseudopapillary carcinoma of pancreas 0 trials
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Gastric carcinoma 92 trials · 555 incl. sub-types
12 sub-types
- Gastric adenocarcinoma 449 trials · 481 incl. sub-types Sub-types →
- Gastric cardia carcinoma 3 trials · 7 incl. sub-types Sub-types →
- Hereditary gastric cancer 1 trial · 6 incl. sub-types Sub-types →
- Gastric squamous cell carcinoma 4 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Epstein-Barr virus-associated gastric carcinoma 1 trial
- Gastric body carcinoma 1 trial Sub-types →
- Undifferentiated carcinoma of stomach 1 trial
- Carcinoma of stomach, salivary gland type 0 trials
- Gastric fundus carcinoma 0 trials Sub-types →
- Gastric pylorus carcinoma 0 trials
- Gastric small cell neuroendocrine carcinoma 0 trials
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Carcinoma of esophagus 76 trials · 509 incl. sub-types
5 sub-types
- Esophageal squamous cell carcinoma 306 trials · 307 incl. sub-types Sub-types →
- Esophageal adenocarcinoma 170 trials · 174 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Esophageal small cell neuroendocrine carcinoma 2 trials
- Carcinoma of esophagus, salivary gland type 0 trials
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Gastroesophageal junction adenocarcinoma 507 trials
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Carcinoma of pharynx 3 trials · 457 incl. sub-types
6 sub-types
- Oropharyngeal carcinoma 100 trials · 243 incl. sub-types Sub-types →
- Nasopharyngeal carcinoma 211 trials · 212 incl. sub-types Sub-types →
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Hypopharyngeal carcinoma 36 trials · 86 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Pharyngeal adenoid cystic carcinoma 0 trials
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Oral cavity carcinoma 16 trials · 202 incl. sub-types
9 sub-types
- Oral cavity squamous cell carcinoma 141 trials · 156 incl. sub-types Sub-types →
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Tongue carcinoma 4 trials
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Carcinoma of hard palate 1 trial
- Carcinoma of soft palate 1 trial
- Intraoral basal cell carcinoma 0 trials
- Oral cavity mucoepidermoid carcinoma 0 trials Sub-types →
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Small intestine carcinoma 19 trials · 105 incl. sub-types
3 sub-types
- Carcinoma of duodenum 21 trials · 75 incl. sub-types Sub-types →
- Small intestine adenocarcinoma 18 trials · 60 incl. sub-types Sub-types →
- Squamous cell carcinoma of the small intestine 1 trial Sub-types →
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Gallbladder carcinoma 41 trials · 49 incl. sub-types
5 sub-types
- Gallbladder adenocarcinoma 9 trials Sub-types →
- Gall bladder carcinoma in situ 0 trials
- Gallbladder small cell neuroendocrine carcinoma 0 trials
- Gallbladder squamous cell carcinoma 0 trials Sub-types →
- Undifferentiated gallbladder carcinoma 0 trials
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Intestine carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Rectum carcinoma in situ 1 trial · 13 incl. sub-types Sub-types →
- Colon carcinoma in situ 3 trials Sub-types →
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Pancreatic endocrine carcinoma 12 trials
2 sub-types
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Digestive system mixed adenoneuroendocrine carcinoma 0 trials · 3 incl. sub-types
1 sub-type
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Carcinoma of floor of mouth 1 trial · 2 incl. sub-types
2 sub-types
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Maxillary sinus carcinoma 1 trial · 2 incl. sub-types
3 sub-types
- Maxillary sinus squamous cell carcinoma 1 trial
- Maxillary sinus adenocarcinoma 0 trials
- Maxillary sinus adenoid cystic carcinoma 0 trials
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Ameloblastic carcinoma 0 trials
Most studied deeper sub-types
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Can a DNA repair weakness make GI tumors vulnerable to lurbinectedin?
Disease control CompletedResearchers are testing lurbinectedin, an intravenous chemotherapy drug, in adults with advanced gastrointestinal cancers that carry mutations in DNA repair genes. The trial enrolls a small group of participants whose tumors are locally advanced or metastatic and who have specifi…
Phase 2 • Sponsor: HonorHealth Research Institute • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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CRISPR-Engineered immune cells take on stomach and colon cancers
Disease control CompletedThis trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…
Phase 1/2 • Sponsor: Intima Bioscience, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Magic mushroom compound tested for cancer anxiety
Symptom relief CompletedThis early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. The study enrolls 24 adults aged 19-85 with stage IV or in…
Phase 1 • Sponsor: University of Nebraska • Aim: Symptom relief
Last updated Aug 21, 2026 00:00 UTC
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Can acupuncture and ice chips beat chemo nerve damage?
Symptom relief CompletedThis phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …
Phase 2 • Sponsor: University of Washington • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Gut bacteria may hold key to better cancer therapy
Knowledge-focused CompletedThis study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…
Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Knowledge-focused
Last updated Sep 21, 2026 20:00 UTC
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Fitness trackers tested in cancer radiation study
Knowledge-focused CompletedThis pilot study looked at whether cancer patients with head and neck, lung, or digestive system cancers could wear a fitness tracker during radiation therapy. The goal was to see if tracking activity levels and quality of life is practical and might relate to treatment outcomes.…
Sponsor: Montefiore Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC