Developmental and epileptic encephalopathy, 2

This study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…

This study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…

This study is testing whether a computer tool called BioEP can detect signs of seizure susceptibility in standard EEG recordings from children with epilepsy. Researchers will analyze past EEGs from 530 children aged 2 to 18 who already have an epilepsy diagnosis. The goal is to s…

This study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…

This pilot study tested a community-based group programme called 'Encompass' for parents of children under 5 with complex neurodisability. Fifteen parents in East London attended ten group sessions over six months. The study aimed to see if the programme was feasible and acceptab…

This study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…