Dermis disorder

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This pilot study tests the drug ivonescimab in people with advanced or metastatic cutaneous angiosarcoma, a rare and aggressive skin cancer. Participants must have already received chemotherapy with paclitaxel or docetaxel. The study aims to see if ivonescimab is safe and can shr…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This study tests whether adding platelet-rich plasma (PRP) to microneedling improves itching and dark patches in macular amyloidosis better than microneedling alone. Thirty adults with the condition will have each side of their face treated differently, and results will be checke…