Cyclic vomiting syndrome
MONDO:0010778A rare functional disorder characterized by recurrent, stereotypical episodes of severe nausea and vomiting separated by symptom-free intervals. Episodes are often accompanied by pallor, lethargy, and abdominal pain. The condition shows a strong association with migraine headaches and may have maternal inheritance patterns suggestive of mitochondrial involvement.
Also known as: cyclic vomiting syndrome, CVS, Cvs-plus, cyclic vomiting syndrome with neuromuscular disease, cyclic vomiting syndrome-plus
8 clinical trials for this condition and its sub-types.
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New nerve zap therapy could ease Kids' mysterious stomach and brain symptoms
Disease control Recruiting nowThis study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Ear nerve stimulator could tame Kids' vomiting episodes
Symptom relief Recruiting nowThis study tests a small device worn on the ear that stimulates the vagus nerve, which helps control nausea and vomiting. Researchers want to see if it can make cyclic vomiting episodes less frequent, shorter, and less severe in 120 children. Half the kids will get an active devi…
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Brain waves under the spotlight: a new clue to cyclic vomiting?
Knowledge-focused Recruiting nowThis study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to compare brain activity in people with cyclic vomiting syndrome (CVS) and healthy volunteers. The goal is to see if there are differences in cortical excitability—how easil…
Phase: NA • Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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2000 patients join effort to unravel mysteries of stomach and gut disorders
Knowledge-focused Recruiting nowThis study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC