Cor pulmonale

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study looked at the safety of using levosimendan over a longer period in people who have both pulmonary hypertension and heart failure with preserved ejection fraction. 35 patients who had already been in a related study received the drug and were monitored for side effects.…

This completed study tested a breathing machine strategy that uses lung pressure measurements to guide settings, aiming to protect the right side of the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators for less than 72 hours were incl…

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces he…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

Researchers compare catheter ablation with medication for people who have heart failure and persistent atrial fibrillation. Half the participants receive ablation to restore normal heart rhythm, and half receive standard drugs to control rate or rhythm. The trial measures changes…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…

This study tested how well three translation tools—ChatGPT, Google Translate, and UD Talk—handle conversations between doctors and patients in Chinese and Japanese during heart and lung checkups. Researchers compared their accuracy and errors using a scoring system. The goal was …

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…

This early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …