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Compartment syndrome
MONDO:0004001Elevated pressure in a confined space enclosed by fascia or eschar, which may lead to vascular compromise and subsequent ischemic injury to the tissue within the space.
Also known as: compartment syndrome
13 clinical trials for this condition and its sub-types.
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Botox for leg pain? new trial tests a surprising treatment
Symptom relief Recruiting nowThis study tests whether injecting Botox into leg muscles can reduce pain during exercise in people with chronic exertional compartment syndrome (CECS). Fifty adults with confirmed CECS will receive either Botox or a placebo injection. Researchers will track pain levels and leg f…
Phase: NA • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Leg pain relief: surgery or exercise? new study aims to find out
Symptom relief Recruiting nowThis study compares two treatments for chronic leg pain caused by compartment syndrome: physiotherapy (with a focus on changing running style) and surgery (fasciotomy). The goal is to see if physiotherapy works as well as surgery, which could help more people avoid an operation. …
Phase: NA • Sponsor: Bispebjerg Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Botox shots before hernia repair may help surgeons close the gap
Symptom relief Recruiting nowThis study tests whether a one-time Botox injection into the side abdominal muscles, given 3-7 weeks before surgery, helps surgeons fully close large ventral hernias. About 188 adults will be randomly assigned to receive Botox or a placebo, and neither they nor their doctors will…
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Tummy tuck breathing study: does surgery pressure harm lungs?
Knowledge-focused Recruiting nowThis study looks at how changing the air pressure in a patient's lungs during a tummy tuck (abdominoplasty) affects their breathing after surgery. Researchers will measure lung pressure before and after the surgeon tightens the belly muscles, and then check lung function afterwar…
Sponsor: Al-Azhar University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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New device could save limbs in sedated ECMO patients
Knowledge-focused Recruiting nowThis study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO. ECMO patients are often sedated and cannot report symptoms, making diagnosis difficult. The device may help doctors diagno…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC