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Compartment syndrome
MONDO:0004001Elevated pressure in a confined space enclosed by fascia or eschar, which may lead to vascular compromise and subsequent ischemic injury to the tissue within the space.
Also known as: compartment syndrome
13 clinical trials for this condition and its sub-types.
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Broader categories
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New Light-Based imaging could spot Limb-Threatening compartment syndrome early
Diagnosis CompletedThis study tested whether a special camera that uses near-infrared light and a dye can help doctors diagnose acute compartment syndrome—a dangerous condition where pressure builds up in muscles after a severe injury. Researchers observed 15 adults with suspected compartment syndr…
Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Diagnosis
Last updated Jun 27, 2026 07:54 UTC
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Can gait retraining or botox shots replace surgery for leg pain?
Symptom relief CompletedThis study tested four non-surgical treatments for chronic exertional compartment syndrome (CECS), a condition that causes leg pain during exercise. 35 active-duty military members were assigned to supervised gait retraining, home-based gait retraining, saline injections, or botu…
Phase: PHASE2 • Sponsor: Walter Reed National Military Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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Botox may help runners avoid surgery for leg pain
Symptom relief CompletedThis study tested whether Botox injections could treat chronic leg pain in runners, a condition called chronic exertional compartment syndrome (CECS). Only 3 people took part, and they received Botox in specific leg muscles. The goal was to see if this could replace surgery, whic…
Phase: PHASE4 • Sponsor: Emory University • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
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Rare leg injury during surgery: new study sheds light on hidden danger
Knowledge-focused CompletedThis study looked at 26 adults having colorectal (bowel) cancer surgery while placed in a steep head-down position with legs raised in stirrups. Researchers measured blood flow and oxygen in the calf muscles during the operation to understand how a rare but serious leg injury cal…
Sponsor: University of Portsmouth • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Scientists probe hidden link between belly pressure and kidneys
Knowledge-focused CompletedThis completed study looked at how a controlled increase in belly pressure (from laparoscopic surgery) affects a hormone called vasopressin and kidney function. Researchers measured pressure, optic nerve size, and urine output in 16 patients having weight-loss surgery. The goal w…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC