Coats plus syndrome
MONDO:0012815Coats plus syndrome is a pleiotropic multisystem disorder characterized by retinal telangiectasia and exudates, intracranial calcification with leukoencephalopathy and brain cysts, osteopenia with predisposition to fractures, bone marrow suppression, gastrointestinal bleeding and portal hypertension. It is transmitted as an autosomal recessive disease.
Also known as: CRMCC, cerebroretinal microangiopathy with calcfications and cysts, cerebroretinal microangiopathy with calcifications and cysts
24 clinical trials for this condition and its sub-types.
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Broader categories
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Hormone drug may slow Aging-Related diseases in rare condition
Disease control CompletedThis study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol fo…
Phase: PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Soothing sounds: slow music eases anxiety during eye procedures
Symptom relief CompletedThis study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…
Phase: NA • Sponsor: Ng Yu Siang • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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New eye scanner aims to sharpen view of retinal disease
Knowledge-focused CompletedThis trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…
Phase: NA • Sponsor: Optos, PLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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AI boosts eye Doctors' accuracy in reading retinal scans?
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) can help doctors detect retinal diseases from ultra-widefield eye images. 462 images were read by four eye doctors with different experience levels, both with and without AI assistance. The goal was to see if AI improves accu…
Sponsor: Xiamen Ophthalmology Center Affiliated to Xiamen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC