Classic familial adenomatous polyposis

This trial tests whether a freezing balloon, called cryoballoon ablation, can safely and effectively remove non-cancerous but potentially precancerous growths (adenomas) in the duodenum, the first part of the small intestine. The study includes people with sporadic adenomas or th…

This study tested whether physiotherapist-led pelvic floor and bowel training could improve bowel function in people who had ileo-anal pouch surgery for ulcerative colitis or familial adenomatous polyposis. Fifty-three participants were randomly assigned to either the behavioural…

This study tested whether adding a transanal (through the anus) approach to standard laparoscopic pelvic pouch surgery could improve outcomes for patients with ulcerative colitis or familial adenomatous polyposis. The transanal method may give surgeons better control and visibili…

This study tested a radioactive tracer called [68Ga]FAPI-46, used with a PET scan, to see if it can better detect pancreatic cancer cells. 63 adults with early-stage pancreatic cancer received the tracer before surgery. The goal was to see how well the scan matches the actual can…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This small, completed study tested a device called NuView in 3 people with familial adenomatous polyposis (FAP). The goal was to see if the device helps doctors view the papilla, a small opening in the intestine, using a standard forward-facing endoscope. Participants had their u…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …