Chordoma
MONDO:0008978Chordomas are rare malignant tumors arising from embryonic remnants of the notochord in axial skeleton.
Also known as: chordoma, chordoma (disease), chordoma, malignant, notochordal sarcoma, CHDM, chordoma, susceptibility to, susceptibility to chordoma
1470 clinical trials for this condition and its sub-types, 30 tagged with Chordoma itself.
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Sub-types of Chordoma
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Skull base chordoma 5 trials
1 sub-type
- Clivus chordoma 0 trials Sub-types →
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Spinal chordoma 3 trials · 4 incl. sub-types
1 sub-type
- Sacrum chordoma 4 trials
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Poorly differentiated chordoma 3 trials
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Chondroid chordoma 0 trials
1 sub-type
- Clivus chondroid chordoma 0 trials
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Old drugs, new hope: imatinib combo tested for rare tumors
Disease control CompletedThis early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…
Phase 1 • Sponsor: Centre Oscar Lambret • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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New drug combo targets Hard-to-Treat cancers in early trial
Disease control CompletedThis early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…
Phase 1 • Sponsor: Erasca, Inc. • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Cancer drug regorafenib tested to halt bone sarcoma spread
Disease control CompletedThis phase 2 trial tests whether the drug regorafenib can stop or slow the growth of metastatic bone sarcomas (cancers that started in bone and spread). 163 patients with osteosarcoma, Ewing sarcoma, chondrosarcoma, or chordoma are randomly assigned to receive regorafenib or a pl…
Phase 2 • Sponsor: UNICANCER • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Promising drug combo targets rare spine tumor
Disease control CompletedThis early-phase study tested the safety of combining the drug nilotinib with standard radiation therapy for people with high-risk chordoma, a rare bone tumor. The goal was to find the highest safe dose of nilotinib that could be given alongside radiation without causing severe s…
Phase 1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Proton beam therapy tested for rare spine and skull base tumors
Disease control CompletedThis study tested proton beam therapy in 54 adults with chordomas or chondrosarcomas, rare tumors of the skull base and spine. The goal was to see if this precise radiation approach is feasible and safe, and to track both short- and long-term side effects. Researchers monitored h…
Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC