Cholesteatoma of middle ear
MONDO:0006533A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Also known as: Epidermosis of ear, Epidermosis of middle ear, cholesteatoma (disease) of middle ear, cholesteatoma of middle ear, cholesteatoma of middle ear and mastoid, cholesteatoma of the middle ear, middle ear cholesteatoma, middle ear cholesteatoma (disease)
6 clinical trials for this condition and its sub-types.
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Broader categories
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New $50 hearing gadget could bring ear checks to remote villages
Diagnosis CompletedThis study tested a low-cost, smartphone-connected device that checks middle ear health. Researchers compared it to standard equipment in 30 adults and children. The goal is to make ear screening affordable and easy for rural communities, reducing preventable hearing loss.
Sponsor: University of Arkansas • Aim: Diagnosis
Last updated Jun 27, 2026 08:10 UTC
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Can a cheap drug make ear surgery safer and faster?
Symptom relief CompletedThis study tested whether a low dose of tranexamic acid, a drug that helps blood clot, could reduce bleeding during middle ear surgery. 100 adults undergoing microscopic or endoscopic ear surgery received either the drug or a placebo. The goal was to see if the drug improved the …
Phase: NA • Sponsor: TC Erciyes University • Aim: Symptom relief
Last updated Jun 26, 2026 14:29 UTC
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Can a tiny camera improve ear surgery? a decade of data puts endoscopic techniques to the test
Knowledge-focused CompletedThis study looks back at 12 years of cholesteatoma surgeries at a French hospital to see how the shift to exclusive endoscopic ear surgery (EES) has affected outcomes. Researchers are comparing rates of residual disease, recurrence, and hearing improvement between patients treate…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC