Cholangitis

This trial tests whether adding radiofrequency ablation to standard chemotherapy and bile duct stenting helps patients with inoperable bile duct cancer. Radiofrequency ablation uses a catheter to deliver heat that destroys tumor tissue blocking the bile duct. Researchers compare …

This study tests whether giving oral antibiotics after Kasai surgery can prevent cholangitis, a serious bile duct infection, in infants with biliary atresia. About 356 babies will be randomly assigned to receive either preventive antibiotics or standard care, and they will be fol…

This study tests whether giving an antibiotic (gentamicin) directly into the bile duct during a procedure called ERCP helps people with acute cholangitis recover faster. About 172 adults with mild to moderate infection will be randomly assigned to receive either the extra antibio…

This study compares two types of sedation used during a procedure to drain blocked bile ducts. About 98 adults will receive either propofol-remifentanil or propofol-ketamine. The goal is to see which method leads to faster recovery, better comfort, and fewer side effects, especia…

This study looks at liver inflammation (hepatitis) that can occur in cancer patients treated with immune checkpoint inhibitors, a type of immunotherapy. Researchers aim to describe the different patterns of liver injury and how they respond to treatment. By collecting real-world …

This study looks at 3,000 people with primary biliary cholangitis (PBC) to see how their blood levels of alkaline phosphatase (ALP) after treatment relate to their risk of liver complications. The goal is to create a model that predicts who will do well and who might need stronge…

This study compares two imaging techniques—laparoscopic ultrasound and a special dye called indocyanine green—to help surgeons see important bile duct structures during difficult gallbladder removal surgery. About 62 adults with conditions like acute cholecystitis, prior abdomina…