Chiari malformation
MONDO:0000115A rare genetic brain malformation characterized by displacement of the brain stem and cerebellum through the foramen magnum. It may result in hydrocephalus.
Also known as: (Arnold) Chiari malformation, Arnold-Chiari malformation, Chiari malformation
11 clinical trials for this condition and its sub-types.
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Broader categories
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Keyhole surgery in the womb could fix spina bifida with fewer risks
Disease control OngoingThis study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Neuro-Patch under the microscope: Real-World surgery study launched
Knowledge-focused OngoingThis study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …
Sponsor: Aesculap AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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MRI study reveals how neck position impacts brain fluid flow
Knowledge-focused ENROLLING_BY_INVITATIONThis study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and pat…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC