Candidiasis

Researchers are testing whether a 5% nanochitosan paste can treat oral candidosis, a fungal infection common under dentures. The trial compares this experimental paste with a standard nystatin ointment in 30 adults who wear full dentures and have type 2 denture stomatitis. Partic…

This study compares a new 1% nanochitosan solution to standard nystatin oral suspension for treating Newton's type II denture stomatitis, a fungal infection causing redness and inflammation under dentures. The trial enrolls 30 complete denture wearers diagnosed by an oral special…

This Phase 2 trial tested an experimental antifungal drug called APX001 (fosmanogepix) in 9 adults with blood or deep-organ infections caused by Candida auris, a fungus that often resists standard treatments. The drug was given by IV or mouth for up to 42 days. The goal was to se…

This study compared two antifungal drugs, fluconazole and micafungin, in 100 newborns with suspected or confirmed candidiasis. The goal was to see if micafungin works as well as the standard treatment fluconazole and to check their safety. The study also looked at how the drugs b…

This pilot study explores whether a PCR-based test can deliver faster results for diagnosing invasive candidiasis in intensive care patients. The trial compares the time to results using this new strategy against standard methods, with the hope of enabling earlier, more targeted …

This study tested a new medicine called rezafungin to see if it can prevent serious fungal infections in adults getting a bone marrow transplant. About 600 participants received either rezafungin or the standard treatment. The goal was to see if rezafungin helps more people stay …

Researchers reviewed hospital records from 1,441 patients to compare fungal infection rates during the SARS-CoV-2 pandemic and afterward. They calculated positivity rates for Candida and Aspergillus species and other fungi. The study examines whether infection control measures ch…

This study looked at better ways to detect Candida (a type of fungus) infections early in intensive care unit (ICU) patients. Researchers tested 422 non-neutropenic adults who had been in the ICU for more than 48 hours. They used four different tests, including blood tests and sw…

This study looked at whether a substance called β-D-glucan in the blood can help identify and track fungal infections in the abdomen (peritonitis) in intensive care patients. Researchers measured levels in 70 adults with peritonitis, comparing those with and without Candida yeast…