Autoimmune thyroid disease

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This study tests whether low-dose colchicine, a drug used for gout, can reduce inflammation and symptoms in people with autoimmune or subacute thyroiditis. About 300 adults will be randomly assigned to colchicine, corticosteroids, or supportive care. The goal is to see if colchic…

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This study tests an investigational drug called efgartigimod for adults with Graves' disease whose thyroid levels are still high despite taking standard antithyroid medications. About 230 participants will receive either the drug or a placebo as a shot under the skin. The goal is…

This study tests a drug called efgartigimod, given as a shot under the skin, for adults with Graves' disease whose thyroid levels are still too high despite taking standard antithyroid drugs. About 230 people will take part, and some will get the drug while others get a placebo. …

This study will test whether a special MRI technique called T1 mapping can find and measure tiny scars in the heart muscle of people with long-term thyroid disease. The goal is to see if this non-invasive scan can replace the need for a heart biopsy. The study plans to enroll 40 …

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This phase 2 trial tests a dye called bevonescein that makes nerves glow during thyroid surgery, helping surgeons see and avoid them. Forty adults having thyroid removal will receive the dye before surgery. The main goal is to see if it improves voice outcomes by reducing nerve i…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study compares two tools used during thyroid removal surgery: LigaSure and bipolar diathermy. The goal is to see which one leads to shorter surgery time, less pain, and fewer complications. Thirty adults having partial or total thyroid removal will take part.

This study tests a computer vision model called PTAIR that helps surgeons identify parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery. About 100 adults with thyroid disease will take part. The model's ability to spot these structures will be compa…

This study will measure how much of the pesticide chlordecone is stored in the thyroid and nearby fat tissue of 69 adults having thyroid surgery in Guadeloupe. Researchers will also look at blood levels and ask about diet and job history to see what factors affect accumulation. T…

This study looks at people with autoimmune thyroid disease (like Hashimoto's or Graves') to see if they have hidden signs of type 1 diabetes risk. Researchers will test blood for diabetes-related antibodies and use genetic data to build a risk model. The goal is to better underst…

This study compares levels of two proteins, Klotho and FGF23, in 150 adults with Hashimoto's thyroiditis versus healthy controls. The goal is to see if these proteins are linked to inflammation in the disease. No treatment is given—only blood samples are taken.

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…