Autoimmune pulmonary alveolar proteinosis

This trial tests whether inhaling molgramostim—a lab-made version of a protein that helps lung cells clear out protein buildup—can improve lung function in adults with autoimmune pulmonary alveolar proteinosis (aPAP). In this condition, the immune system blocks a key signal, caus…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This early-phase study tests a new type of CAR-T cell therapy in 9 people with autoimmune diseases that have not responded well to standard treatments. The therapy uses specially engineered immune cells to target and attack faulty immune cells. The main goal is to check safety an…

This study compares a new AI-assisted digital system to the standard manual method for reading Pap tests. About 4,600 cervical cell samples will be reviewed both ways to see if the AI system is just as good at detecting abnormal cells. The goal is to determine if the AI can help …

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This registry enrolls up to 1,000 women aged 12–55 with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Researchers will collect data from medical records and patient surveys to study pregnancy outcomes, disease activity, and medication use. No experiment…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…