Autoimmune encephalopathy with parasomnia and obstructive sleep apnea
MONDO:0018489Autoimmune encephalopathy with parasomnia and obstructive sleep apnea is a rare neurologic disorder characterized by a unique non-REM and REM parasomnia with sleep breathing dysfunction, gait instability and repetitive episodes of respiratory insufficiency, as well as autoantibodies against IgLON5. Patients may present stridor, chorea, limb ataxia, abnormal ocular movements, and bulbar symptoms (i.e. dysphagia, dysarthria, episodic central hypoventilation) with normal brain MRI. Excessive day sleepiness and cognitive deterioration have also been reported.
Also known as: anti-IgLON5 disease, anti-IgLON5 syndrome
60 clinical trials for this condition and its sub-types.
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Experimental drug aims to tame stubborn autoimmune diseases
Disease control Not yet recruitingThis early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …
Phase: NA • Sponsor: Starna Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug STR-P005 aims to tame stubborn autoimmune diseases
Disease control Not yet recruitingThis early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …
Phase: NA • Sponsor: Beijing GoBroad Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Could one antibiotic dose before tooth pulling prevent infections in Immune-Weakened patients?
Prevention Not yet recruitingThis study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …
Phase: PHASE4 • Sponsor: University of Sao Paulo General Hospital • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Can a narcolepsy drug fix ICU sleep problems?
Symptom relief Not yet recruitingThis study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Can a bedtime pill fix sleep troubles in kids with anorexia?
Symptom relief Not yet recruitingThis study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…
Phase: PHASE3 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Sleep therapy could be key to preventing suicide in young adults
Symptom relief Not yet recruitingThis study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…
Phase: NA • Sponsor: University of Pittsburgh • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Can hospitals boost vaccine access for the most vulnerable?
Knowledge-focused Not yet recruitingThis study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC