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Antisynthetase syndrome

MONDO:0019344

Antisynthetase (AS) syndrome is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease (ILD), and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS).

Also known as: AS syndrome, anti-Jo1 syndrome

27 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Inflammatory disease (332) Musculoskeletal system disorder (207) Myositis disease (98) Acquired idiopathic inflammatory myopathy (64) Idiopathic inflammatory myopathy (57) Muscle tissue disorder (56) Human disease (14) Myopathy (14) Skeletal muscle disorder (10)
Trials to join now! 14 Not yet recruiting 2 Not yet finished but already full! 4 Completed 6 Terminated 1
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  • Lung disease drug tested in rare muscle condition – trial cut short

    Disease control Terminated

    This study tested the drug nintedanib (Ofev) in 11 people with myositis-related interstitial lung disease, a condition where lung scarring occurs alongside muscle inflammation. The goal was to see if the drug is safe and tolerable when added to standard immune-suppressing treatme…

    Phase: NA • Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Disease control

    Last updated Jun 26, 2026 13:17 UTC

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