Anti-NMDA receptor encephalitis
MONDO:0021081An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor.
Also known as: anti-NMDA receptor encephalitis, limbic encephalitis with N-methyl-D-aspartate receptor antibodies, limbic encephalitis with NMDA receptor antibodies
10 clinical trials for this condition and its sub-types.
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Blood-Filtering therapy may tame rare brain inflammation in children
Disease control CompletedThis trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Healthy volunteers help test new drug for brain inflammation
Knowledge-focused CompletedThis early-stage study tested a single dose of a new drug called ART5803 in 7 healthy adults to see if it is safe and how it interacts with another medicine (IVIG). The goal was to gather information for future research on autoimmune encephalitis, a condition where the immune sys…
Phase: PHASE1 • Sponsor: Arialys Therapeutics • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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MRI contrast dye may skew brain scans, study finds
Knowledge-focused CompletedThis study looked at how gadolinium, a dye used in MRI scans, changes the QSM signal in the brain's white matter. 73 patients with inflammatory central nervous system conditions had MRI scans before and after receiving gadolinium. The goal was to measure any differences in the si…
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Life after a rare brain disease: what happens to patients in the long run?
Knowledge-focused CompletedThis study looked at 20 adults who had NMDA receptor encephalitis, a rare brain condition that can cause psychosis, memory loss, and seizures. Researchers used questionnaires to measure thinking skills, mood, fatigue, and quality of life after the acute phase. The goal was to und…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC