Acute hemorrhagic leukoencephalitis
MONDO:0011716Acute hemorrhagic leukoencephalitis(AHL) is a veryrareform of acute disseminated encephalomyelitis that usuallyresults indeath. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting,seizures, and coma.AHL has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. Although the exact cause is unclear,AHL usually followsaviral infection, or less often, vaccination for measles, mumps, or rubella. Some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to AHL.
Also known as: AHL, acute hemorrhagic leukoencephalitis, AHLE, Ahl
11 clinical trials for this condition and its sub-types.
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Can a cancer drug reboot the immune system in chronic fatigue syndrome?
Disease control Not yet recruitingThis trial tests whether inebilizumab, an antibody that wipes out certain immune cells called B cells, can improve physical function in adults with ME/CFS that started after an infection. Participants receive three infusions over six months, and the study measures changes in mobi…
Phase: PHASE2 • Sponsor: Charite University, Berlin, Germany • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Rapid brain infection test could slash unnecessary antibiotic use
Diagnosis Not yet recruitingThis study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …
Phase: NA • Sponsor: Federal University of Health Science of Porto Alegre • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Hidden heart risks in kids with brain conditions?
Knowledge-focused Not yet recruitingThis study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:21 UTC