Acquired hemophilia
MONDO:0019139Acquired hemophilia is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia occurs when the body's immune system attacks and disables a certain protein that helps the blood clot. About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications.
Also known as: acquired hemophilia, hemophilia, acquired
18 clinical trials for this condition and its sub-types.
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New drug OBIZER monitored in rare bleeding disorder study
Disease control Recruiting nowThis study tracks 25 people in Japan with acquired hemophilia A who receive the drug OBIZER to control bleeding. Researchers will watch for side effects and check if the drug helps stop bleeding episodes. The study does not change how doctors treat patients—it simply collects rea…
Sponsor: Takeda • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Could a clotting booster cut blood loss in ICU patients?
Disease control Recruiting nowThis study looks at whether adding a drug called Wilate (a von Willebrand factor concentrate) to standard platelet transfusions can reduce bleeding and the need for more blood products in intensive care patients. About 120 adults who need platelets during or after surgery will be…
Phase: PHASE4 • Sponsor: University Hospital, Basel, Switzerland • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New study monitors OBIZUR's safety in rare bleeding disorder
Disease control Recruiting nowThis study is checking how safe OBIZUR is for adults with acquired hemophilia A, a rare condition that causes sudden and severe bleeding. Researchers will look at medical records and track side effects in about 9 people. The goal is to see how well the drug controls bleeding in e…
Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Hormonal showdown: which treatment tames heavy periods in bleeding disorders?
Disease control Recruiting nowThis study follows 300 teens and young adults (ages 10-24) with inherited bleeding disorders who choose either a levonorgestrel IUD or norethindrone acetate pills for heavy menstrual bleeding. Researchers will track bleeding patterns, satisfaction, and quality of life over six mo…
Sponsor: Oregon Health and Science University • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Can hormones tame heavy periods in teens with bleeding disorders? new study aims to find out.
Knowledge-focused Recruiting nowThis study follows 163 teens and young adults with heavy menstrual bleeding, some with a bleeding disorder and some without, to see how well hormonal treatments like the pill, patch, or IUD work. Researchers will measure blood loss, quality of life, and iron levels over time. The…
Sponsor: University Hospital, Geneva • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Massive blood disorder registry aims to transform care
Knowledge-focused Recruiting nowThis study is a large registry that collects health information from up to 200,000 people with blood disorders such as hemophilia, thrombosis, and sickle cell disease. Participants are seen at Hemophilia Treatment Centers across the U.S. The goal is to gather real-world data to h…
Sponsor: American Thrombosis and Hemostasis Network • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New study tracks joint replacement success in bleeding disorder patients
Knowledge-focused Recruiting nowThis study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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New registry aims to uncover dengue risks for bleeding disorder patients
Knowledge-focused Recruiting nowThis study creates a registry to collect data on dengue infections in people with congenital bleeding disorders like hemophilia. Dengue can cause serious bleeding, and those with bleeding disorders may face higher risks. The goal is to understand bleeding complications, treatment…
Sponsor: Mahidol University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Could low serotonin in blood platelets be a hidden cause of bleeding?
Knowledge-focused Recruiting nowThis study looks at 50 adults with unexplained bleeding to see if low serotonin levels in their platelets are linked to their symptoms. Researchers will use a standard bleeding questionnaire to measure bleeding severity. The goal is to better understand how serotonin deficiencies…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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New blood tests aim to make haemophilia treatment safer for patients with inhibitors
Knowledge-focused Recruiting nowThis study is testing new blood tests to see if they can better measure how well bleeding treatments work in people with haemophilia who have developed inhibitors (antibodies that block standard treatment). The researchers will take blood samples from 20 patients before and after…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:42 UTC