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Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome

MONDO:0008696

This syndrome is characterized by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy.

Also known as: acanthosis nigricans muscle cramps acral enlargement, acanthosis nigricans with muscle cramps and acral enlargement, familial insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps

1 clinical trial for this condition and its sub-types.

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Broader categories

Disease (717) Inflammatory disease (341) Skin disorder (135) Dermatitis (64) Human disease (15) Acanthosis nigricans (4) Disease by body system or component (0) Disease by developmental or physiological process (0) Epidermal disease (0) Integumentary system disorder (0)
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  • Can immune fingerprints unlock new treatments for skin disease?

    Knowledge-focused Not yet recruiting

    This observational study aims to map the immune and molecular profiles of people with inflammatory skin conditions, including genetic forms like epidermolysis bullosa. By comparing these profiles to those of healthy individuals, researchers hope to identify unique signatures that…

    Sponsor: Guy's and St Thomas' NHS Foundation Trust • Aim: Knowledge-focused

    Last updated Aug 20, 2026 00:00 UTC

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