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127005 trials found · Page 5485 of 6351
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Could a common anxiety drug and melatonin lift depression after brain injury?
Symptom relief Recruiting nowTraumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conducted a pilot clinical trial, which investigated the novel treatment combination o…
Phase 4 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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New support program aims to ease lung cancer patients' transition to survivorship
Symptom relief OngoingThis research study is designed to develop and test a new supportive care program to help individuals with lung cancer improve their quality of life after cancer treatment is over.
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Mystery autumn allergies traced to birch rust?
Knowledge-focused CompletedIn this project we study if spores from birch rust fungi (Melampsoridium Betulinum = MB) may be the eliciting allergen in patients with seasonal airway allergy during autumn in North Norway. Patients with suspected allergy to MB are compared with non-allergic controls using data …
Sponsor: University Hospital of North Norway • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Study maps hidden nerve damage in head and neck cancer survivors
Knowledge-focused Recruiting nowFollowing preliminary studies carried out in our department on these subject and subjective findings during clinical examinations, it has been shown that pain is a symptom that is rarely reported following treatment. Instead, neurosensory disorders such as hypoesthesia and parest…
Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:45 UTC
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HIV drug fails to prove COVID-19 prevention in abandoned trial
Prevention Stopped earlyA randomized parallel double-blinded placebo-controlled clinical trial to evaluate the effect of Emtricitabine/Tenofovir alafenamide (FTC/TAF) compared with placebo on the risk of developing SARS-CoV-2 disease (COVID-19) in healthcare workers with high transmission risk in additi…
Phase 3 • Sponsor: Hospital Italiano de Buenos Aires • Aim: Prevention
Last updated Jun 26, 2026 14:58 UTC
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New HIV shot formula tested for safety and absorption
Knowledge-focused CompletedThis is an active control, randomized study to investigate the safety, tolerability and PK of repeat dose administration of long-acting CAB 400 mg/mL formulation intramuscular (IM) (gluteus medius and vastus lateralis) and subcutaneous (SC) (abdominal) injections in healthy adult…
Phase 1 • Sponsor: ViiV Healthcare • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Mayo clinic study probes immune secrets of breast cancer drugs
Knowledge-focused Recruiting nowThis study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The info…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Anesthesia choice may influence blood loss in hip fracture surgery
Knowledge-focused CompletedThis retrospective observational study evaluates the effect of different regional anesthesia techniques on perioperative blood loss in patients undergoing femoral neck fracture surgery. Patients who received tranexamic acid were grouped by anesthesia method (lumbar plexus block, …
Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Can a simple workshop help arab women better manage their heart health?
Knowledge-focused CompletedThis is a two-stage study: The objective of the first stage is to explore health literacy (HL) needs and preferences of Arab women through conducting Focus Group Discussions (FGDs). The second stage will employ conducting a HL intervention tailored to the participants' needs and…
Sponsor: Hadassah Medical Organization • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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New device tracks Kids' lung health during anesthesia
Knowledge-focused CompletedThis study investigates under controlled conditions the variation of poorly ventilated lung units (silent spaces) in children between 1 and 6 years of age measured by electrical impedance tomography during intravenous anaesthesia in a day-hospital setting and before discharge to …
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Train transfers for COVID ICU patients: did it work?
Knowledge-focused CompletedSince early 2020, France knows a sanitary crisis with a massive influx of COVID-19 patients admitted in Intensive Care Units (ICU). It led to a saturation of the French health system, especially in some geographic areas such as East of France or Paris region. Therefore, authoriti…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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French hospital staff antibody study reveals infection patterns
Knowledge-focused CompletedHospital staff, on the front line in the COVID-19 crisis, have many questions about the risk that they have been infected with this potentially fatal virus. These questions of course primarily concern caregivers working in sectors dedicated to COVID-19 patients, whether they are …
Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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New drug combo aims to wipe out hidden leukemia cells
Disease control Stopped earlyThis phase II trial studies how well ABL001 works in treating patients with chronic myeloid leukemia who are on therapy with tyrosine kinase inhibitor. ABL001 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving ABL001 and tyrosine ki…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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How many kids had COVID? new study counts antibodies
Knowledge-focused CompletedThe purpose of this study is to provide data on the proportion of seroconverted children and their immune status. It will also provide insight into the number of children currently infected at each time point including healthy carriers. Investigators will provide similar data on …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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3D printed button may ease ostomy anxiety before surgery
Symptom relief CompletedThe making of an ostomy in patients is experienced as traumatic. The stoma changes body image, self-esteem and is responsible for increased anxiety. These changes affect the quality of life of patients. To reduce the negative impact of the stoma, patients are seen in preoperative…
Sponsor: Centre Hospitalier Departemental Vendee • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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New study peers inside lungs to uncover cystic fibrosis damage
Knowledge-focused OngoingIn this project, the investigators seek to understand the role of endothelial cells in Cystic Fibrosis (CF) lung disease. This objective will be achieved by conducting a cross sectional clinical study to define the morphology of the pulmonary circulation across a range of lung fu…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Crohn's surgery showdown: which technique wins?
Disease control Stopped earlyStudy description - Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn's disease. The primary endpoint 6-month endoscopic recurrence. Endpoints -…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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French study to reveal true COVID-19 infection rates during lockdown easing
Knowledge-focused Recruiting nowThis is a prospective observational cohort study that will define the prevalence and incidence of CA-SARS-Cov2 infection using serological and PCR tests in a group of subjects during deconfinement. The team wishes to include approximately 1000 subjects in this study. The health …
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Blood marker may predict cancer return in testicular tumor patients
Knowledge-focused OngoingThis trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the c…
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Ozempic's Long-Term safety tracked in over 3,200 diabetes patients
Disease control CompletedThe purpose of this study is to assess the safety of long-term treatment with Ozempic® in patients with type 2 diabetes mellitus. People will get Ozempic® as prescribed by their doctor. People will be in this study about 3 years. People above the age of 18 will be asked to fill i…
Sponsor: Novo Nordisk A/S • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC