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116076 trials found · Page 5125 of 5804
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Brittle bone disease linked to severe teeth misalignment – new study investigates
Knowledge-focused OngoingOsteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss and pain and difficulty getting around. People with moderate to severe OI ma…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Worried before gum surgery? study links anxiety to slower recovery
Knowledge-focused CompletedThis study investigates the effect of free gingival graft (FGG) surgery on patients' oral health-related quality of life (QoL) during the first postoperative month and evaluates the role of preoperative anxiety on postoperative QoL outcomes. Thirty-six participants indicated for …
Phase: NA • Sponsor: Istanbul Gelisim University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Tiny implants, big smile: short teeth screws could replace bone grafts
Disease control CompletedThis study aims to compare the clinical performance of 4 mm short implants supporting cross-arch fixed reconstructions in the edentulous mandible either with a combination of two short implants as distal support and two implants of conventional length placed in the interforaminal…
Phase: NA • Sponsor: Institut Straumann AG • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Which strategy gets more people screened for colon cancer? study finds out
Knowledge-focused CompletedThe purpose of this study is to determine whether inreach and outreach strategies will be superior to usual care, and combination of both will be superior to either strategy alone.
Phase: NA • Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:55 UTC
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Brain study reveals secrets of placebo effect in depression
Knowledge-focused CompletedIn summary, the proposed research is novel with respect to design, technology, and its multi-level integration probing psychological and neurobiological constructs assumed to be crucially implicated in placebo response and has significant clinical and research implications for th…
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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3D-Printed sleep masks aim to help kids breathe easier
Symptom relief CompletedThis is a small pilot study to look at the feasibility of creating a customized sleep mask for use with Continuous Positive Airway Pressure (CPAP) or other similar treatments for sleep apnea. The participant will have three dimensional (3D) pictures of the face taken by special c…
Phase: NA • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Stomach signals may unlock secrets of food addiction
Knowledge-focused CompletedThe purpose of this exploratory study is to use Electrogastrography (EGG) to measure and compare the gastric myoelectrical activity between persons with food addiction (FA) and a control group. Additionally, this study will explore if differences exist between perceived hunger an…
Sponsor: Texas Tech University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Teen Self-Harm study uses brain scans to uncover clues
Knowledge-focused CompletedThis study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI). Specifically, three constructs outlined by the Research Domains Criteria (RDoC) will be examined through self-assessment, MRI, and a cognitive batte…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Can community health workers help chinese smokers get screened for lung cancer?
Knowledge-focused CompletedThe purpose of this study is to test if our Community Health Worker program can help at-risk NYC Chinese community members participate in shared decision making and lung cancer screening (if appropriate) and compare it to the help provided by written materials.
Phase: EARLY_PHASE1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Late-Night snacks and booze: a recipe for colon cancer?
Knowledge-focused OngoingThe purpose of this study is to study the impact of Western lifestyle, including moderate alcohol consumption and delayed eating patterns on studying individuals' susceptibility to colorectal cancer. This study aims to increase our ability to identify individuals at risk for colo…
Phase: NA • Sponsor: Rush University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Deeper feeding tube may ease stomach issues in Face-Down lung patients
Knowledge-focused CompletedEvidence remains limited regarding the optimal enteral nutrition (EN) route for acute respiratory distress syndrome (ARDS) patients undergoing prone positioning. This study aimed to explore the association of post-pyloric feeding with feeding intolerance (FI), specifically in tha…
Sponsor: Southeast University, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Shorter antibiotic course may be just as good for facial fractures
Knowledge-focused CompletedFacial fractures make up a significant proportion of injuries in trauma patients (1, 2). Approximately 3 million individuals suffer craniofacial trauma in the United States on a yearly basis, and approximately 50% of all wounds presenting to emergency rooms involve the head and n…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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New MRI technique could unlock secrets of stroke damage
Knowledge-focused CompletedCerebral vascular disorder is one of the most fatal diseases despite current advances in medical science. The large number of negative clinical trials on neuroprotection in acute stroke is a pointer to the fact that translating better understanding of the pathogenesis and pathoph…
Phase: NA • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:46 UTC
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Sleep apnea may be hidden danger for type 1 diabetes patients
Knowledge-focused CompletedPatients with type 1 diabetes have poorer glycemic control that could lead to macrovascular or neuropathic complications; in addition to an optimal treatment, prevention of diabetes complications requires to control associated risk factors, such as hypertension or dyslipidemia. S…
Sponsor: University Hospital, Grenoble • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New blood test could help patients who Don't respond to platelet transfusions
Knowledge-focused CompletedBackground: Platelets are blood cells that help blood clot. Some people have what is called thrombocytopenia. This means they have a low blood platelet count. They need platelet transfusions very often. Human leukocyte antigen (HLA) alloimmunization occurs for a lot of these peo…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Brain radiation may erase personal memories, study warns
Knowledge-focused CompletedSeveral studies showed that radiotherapy as brain tumors treatment may affect cognition. It was observed that durable memory impairments could arise at irradiated patients if radiotherapy is applied on medial temporal lobes. However, results concerned studies of anterograde memo…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Eye disease biobank seeks clues to uveitis
Knowledge-focused CompletedBackground: Uveitis is a serious eye disease that can cause vision loss. Treatment sometimes causes serious side effects or does not work. Researchers want to learn more about uveitis and why some people develop it. Objective: To learn clinical and genetic factors that may mak…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Heart stent study halted early: can a pressure wire improve outcomes?
Knowledge-focused TerminatedThe purpose of this study is to evaluate the effect of FFR (Fractional flow reserve) guided Percutaneous Coronary Intervention in coronary tandem lesions.
Sponsor: Seung-Jung Park • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Couples' emotions studied in breast cancer journey
Knowledge-focused CompletedThe KALICOU 3 study will evaluate the effect of emotional skills of patients and their partners on their individual disease subjective experience during care pathways, from chemotherapy to surveillance.
Phase: NA • Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Can a simple talk help men with prostate cancer make better choices?
Knowledge-focused Recruiting nowInvestigators propose an observational interview study to explore how patients understand treatment conversations with their physicians within the framework of health literacy. The study team will test whether patients' understanding of treatment options and side effects can be i…
Phase: NA • Sponsor: Emory University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC