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116076 trials found · Page 4227 of 5804
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Unlocking hand recovery: how assistive devices reshape muscle coordination after stroke
Knowledge-focused Recruiting nowThe experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform extension movements of the index finger of their more-impaired (stroke) or nondominant (control) hand under two different assistance types: end-effector assistance and…
Phase: EARLY_PHASE1 • Sponsor: The Catholic University of America • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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New study seeks to unravel the mystery of Post-Stroke fatigue
Knowledge-focused Recruiting nowThis study aims to determine the frequency of post-stroke fatigue (PSF) in patients experiencing their first-ever stroke and admitted to our clinic. PSF is a common and debilitating condition that significantly impacts patients' recovery and quality of life. The study will also e…
Sponsor: Ankara University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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New Dual-Action drug targets Hard-to-Treat kidney cancer
Disease control TerminatedThis is a single-center, phase I study. Patients with metastatic clear cell renal cell carcinoma will be recruited in this study to (Phase A) evaluate using 68Ga-NYM096 PET/CT and to (Phase B) treat with 177Lu-NYM096. The study will be conducted in two phases. The purpose is Pha…
Phase: PHASE1 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Touch vs. ultrasound: which finds the emergency airway spot faster?
Knowledge-focused CompletedParticipants will be anesthesiologists, who will identify the cricothyroid membrane on a silicone model of the neck with either palpation or ultrasonography. The participants can choose either the "String of pearls" or Thyroid-Airline-Cricoid-Airline (TACA) for the ultrasonograp…
Phase: NA • Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Can zapping the brain help Parkinson's patients walk again?
Symptom relief Recruiting nowThe goal of this clinical trial is to learn whether a personalized brain stimulation method called repetitive transcranial magnetic stimulation (rTMS), combined with walking exercises, is a practical and tolerable approach to help people with Parkinson's disease who experience fr…
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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New drug ORB-021 enters early human testing for advanced cancers
Disease control Recruiting nowThe goal of this clinical research study is to determine if an investigational new drug, named ORB-021, developed by Orionis Biosciences is safe and can be tolerated in people diagnosed with an advanced solid tumor. The study also aims to find the biologically optimal dose of th…
Phase: PHASE1 • Sponsor: Orionis Biosciences Inc • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Robotic surgery heart risk study: can fragile patients handle the tilt?
Knowledge-focused Recruiting nowThe field of robotic-assisted laparoscopic surgery increases all the time. Older and more fragile patients which are not suitable for major open surgery could be scheduled for robotic- assisted surgery. The peroperative anesthesiological challenges and stresses during this type o…
Sponsor: Karlstad Central Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Alzheimer's agitation drug safety trial ends early
Disease control TerminatedThe primary objective of this open-label extension trial was to evaluate the long-term safety of AXS-05 for the treatment of Alzheimer's disease agitation in subjects that participated in ADVANCE-2 or ACCORD-2.
Phase: PHASE3 • Sponsor: Axsome Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Which workout wins for fast bowlers? TRX vs foundation training
Knowledge-focused CompletedFast bowling in cricket is an intense, high-impact activity requiring a blend of strength, power, and endurance to maintain performance and reduce injury risk. The unique physical demands of fast bowling involve repeated explosive movements, placing stress on the bowler's core, s…
Phase: NA • Sponsor: Riphah International University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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New Balloon-Expandable heart valve tested in just 8 patients
Disease control OngoingEarly System Experience with the Abbott Balloon-expandable TAVI System
Phase: NA • Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Can a phone app tame workplace burnout for officers working with troubled youth?
Symptom relief OngoingThis feasibility clinical trial aims to assess the feasibility of implementing a 1-month app-based meditation program with officers in the juvenile legal system and other professionals working directly with legal-involved youth.
Phase: NA • Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Promising FNAIT prevention study halted early after just one participant
Prevention TerminatedThe purpose of this Phase 2 study is to assess the pharmacokinetics (PK) and safety of RLYB212 in HPA-1b/b pregnant women at higher risk for HPA-1a alloimmunization and FNAIT.
Phase: PHASE2 • Sponsor: Rallybio • Aim: Prevention
Last updated Jun 27, 2026 09:11 UTC
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Sound waves could replace biopsies for gut scarring detection
Knowledge-focused Recruiting nowProspective multicenter interventional non-randomized cross-sectional study. Ultrasound operators will be blinded to clinical and endoscopic findings and the endoscopist will be blinded of the clinical and ultrasound findings. This study aims to develop novel imaging and molecul…
Phase: NA • Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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New knee shot for arthritis passes first safety check
Symptom relief CompletedThis is a randomized, placebo-controlled, participant- and Investigator-blinded Phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of ascending single intra-articular doses of SAR446959 in female and male participants with osteoarthritis of t…
Phase: PHASE1 • Sponsor: Sanofi • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Early childhood program shows lasting impact on Kids' brains
Knowledge-focused CompletedThis study is designed to evaluate the impact of the RINEW multicomponent early child development intervention on child development and risk factors for poor child development in middle childhood. This study is a follow-up assessment of the children and primary caregivers enrolle…
Phase: NA • Sponsor: University of California, Berkeley • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Scientists hunt for genetic clues linking gum disease and heart trouble
Knowledge-focused OngoingPeriodontitis is a chronic multifactorial inflammatory disease associated with the accumulation of dental plaque and characterized by progressive destruction of the teeth-supporting apparatus, including the periodontal ligament and alveolar bone. Dental plaque accumulation at the…
Phase: NA • Sponsor: Meenakshi Ammal Dental College and Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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AI analyzes heart failure Patients' stress and health literacy to predict quality of life
Knowledge-focused CompletedHeart failure is showing a trend of affecting younger individuals. Middle-aged heart failure patients are often the economic backbone of their families. Studies have also pointed out that approximately 38.5% of patients with acute heart failure are re-hospitalized within a year o…
Sponsor: Cheng-Hsin General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Morphine in spinal epidural may reduce breakthrough labor pain
Symptom relief Recruiting nowNeuraxial analgesia has shown to be the gold standard for effective labor pain relief, offering numerous benefits including enhanced pain control and maternal satisfaction. The methods to achieve neuraxial analgesia include lumbar epidural (LE), and combined spinal epidural (CSE)…
Phase: NA • Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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470 patients studied to map ancient medicine patterns in modern diabetes
Knowledge-focused CompletedThis study aims to include type 2 diabetes (T2DM) patients comorbid with metabolic syndrome (MetS). The primary aim of the study is to investigate the TCM (Traditional Chinese Medicine) syndrome differentiation of T2DM comorbid with MetS.
Sponsor: Hong Kong Baptist University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Eye workouts boost balance in young athletes
Symptom relief CompletedThe goal of this interventional study is to evaluate the effects of a six-week eye-movement exercise program on balance in athletes aged 15 to 30 years participating in basketball, football, and boxing. The main question it aims to answer whether performing daily exercises based …
Phase: NA • Sponsor: Sport University of Tirana • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC