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App-Based therapy shows promise for IBS relief

NCT ID NCT04665271

Symptom relief Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a smartphone app called Zemedy, which delivers cognitive-behavioral therapy, can improve quality of life and reduce symptoms in adults with Irritable Bowel Syndrome (IBS). Over 450 participants used either Zemedy or a relaxation training app for comparison. The goal was to see if a digital, self-guided therapy is an acceptable and effective way to manage IBS.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Zemedy app (digital cognitive-behavioral therapy)
What this could lead to
If it works, this could offer a convenient, app-based way to manage IBS symptoms and improve quality of life without medication.
What could go wrong
This is a completed trial comparing two apps, not a new drug. Results may show only modest benefits, and the app may not work for everyone with IBS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

453 people

The number who actually took part.

Started

Mar 2021

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Self-report of physician diagnosis of IBS. * At least 18 years of age. Exclusion Criteria: * Severe depression or suicidality * Comorbid GI disorder such as inflammatory bowel disease or celiac disease. * Pregnancy

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irritable bowel syndrome

Contacts and locations

Locations

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104-6018, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.