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New hope for rare blood cancer: drug cocktail targets stubborn LCH

NCT ID NCT07204041

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 32 times

Summary

This study tests a three-drug combination (selinexor, thalidomide, and dexamethasone) in 40 adults with a rare blood disorder called Langerhans cell histiocytosis (LCH) that has not responded to or has returned after prior treatment. The goal is to see if the regimen can control the disease and improve survival. Participants will receive the drugs and be monitored for side effects and disease progression.

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Contacts and locations

Locations

  • Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, beijing,

    Beijing, China

Conditions

Explore the condition pages connected to this study.