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Can a steroid and a gel make wisdom tooth recovery less painful?

NCT ID NCT07317596

Symptom relief Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving methylprednisolone (a steroid) before surgery and placing hyaluronic acid (a natural gel) in the tooth socket after extraction can reduce pain, swelling, and jaw stiffness after wisdom tooth removal. Forty healthy adults having a wisdom tooth pulled will be randomly assigned to receive one or both treatments, or standard care. The goal is to find a better way to manage common post-surgery discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
methylprednisolone and hyaluronic acid
What this could lead to
If successful, this could provide a simple, safe way to reduce pain, swelling, and jaw stiffness after wisdom tooth removal, improving recovery for many people.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The treatments are already used in other contexts, so major breakthroughs are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient medically healthy. 2. Patient between the ages of 18 and 40 3. Patient had impacted mandibular third molar indication for extraction( mesio angler full impaction) 4. Patients who were cooperative, motivated, to attend the follow-up Exclusion Criteria: 1. Pregnant women, children, elderly (\>40 years), physically and mentally challenged, terminally and seriously ill. 2. Patients who had severe pericoronitis, concomitant carious and/or periodontal disease. 3. Patient who had contraindications to the medicines or anesthetics. 4. Uncooperative Patients who won't be able to maintain the follow up visits.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hyaluronic acid Methylprednisolone Post operative complications Wisdom tooth removal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sana'a University

    Sanaa, 0000, Yemen

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