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Can a simple test predict your weight loss success?

NCT ID NCT02043457

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study from the University of Michigan is recruiting 3,200 people to understand why some people lose weight and keep it off while others struggle. Participants will undergo a range of tests, including blood work, body composition scans, and fitness assessments. The goal is to identify biological and behavioral factors that predict weight loss success, moving away from a one-size-fits-all approach to obesity treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to personalized weight loss plans based on individual biology and lifestyle, making weight management more effective.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear predictors, and results may not apply to everyone with obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,200 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Aug 2009

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

3000 obese participating in a 2 year clinical weight loss and weight maintenance program and 200 lean controls may opt-in to participate in a number of evaluations including depression inventory and HRQOL questionnaires, assessing hunger and appetite, work performance (including presenteeism and absenteeism), pain survey, oral glucose tolerance testing, mixed meal tolerance testing with metabolomics, DNA, RNA, with or without muscle and adipose tissue biopsies, body composition by DEXA or BodPod, measurements of REE and V02 max before at baseline, at 10-15% weight loss and after the 2 year clinical program.

Ages

15 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2 * Lean population BMI \< 27 but \> 17 kg/m2 * Able and willing to provide written informed consent for the trial Exclusion Criteria: * Evidence of inherited disorders of lipid metabolism. * History of Cancer within the last 5 years * Human immunodeficiency virus (HIV) antibody positive. * Patients with solid organ transplants. * Participation in any other clinical trial within 90 days of entry into this trial. * Pregnant or lactating females. * Uncontrolled thyroid disease * Unstable angina or NY heart association class II failure or above * Gastrointestinal disease specifically GI motility disorders * Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia * End stage renal or hepatic disease * Autoimmune disorders (e.g. SLE) * Body weight fluctuation of more than 5 kg in the previous 3 months * Prior bariatric surgery * A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months. * Women of childbearing age must use a reliable form of contraception. * Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol. * Unwilling or unable to consent for the study.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.