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Weekly shot for high cholesterol? new trial tests more frequent dosing

NCT ID NCT07477704

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 6 times

Summary

This study tests whether a weekly dose of alirocumab (Praluent) is safe and effective for adults with high cholesterol. Alirocumab is already approved for use every two weeks, but this trial explores if giving it weekly works better. About 420 participants will receive different weekly doses, and researchers will track how much their LDL ('bad') cholesterol drops and watch for side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
alirocumab (Praluent)
What this could lead to
If successful, this could show that weekly dosing of alirocumab is a safe and effective option for lowering high cholesterol.
What could go wrong
This is a mid-stage trial with 420 participants, so results are not final. The weekly dose may cause more side effects or not work better than the approved every-two-week regimen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 420 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1\. Participant has elevated LDL-C level, as defined in the protocol Key Exclusion Criteria: 1. Participant plans to initiate or change dose of lipid-lowering therapy 2. Use of any PCSK9 inhibitors NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

Hypercholesterolemia hyperlipidemia Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypercholesterolemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    34 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AMR Norman

    RECRUITING

    Norman, Oklahoma, 73069, United States

  • Accellacare of Wilmington

    RECRUITING

    Wilmington, North Carolina, 28401, United States

  • Altoona Center for Clinical Research

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Anaheim Clinical Trials

    RECRUITING

    Anaheim, California, 92801, United States

  • Balanced Life Health Care Solutions

    RECRUITING

    Lawrenceville, Georgia, 30046, United States

  • Be Well Clinical Studies - Round Rock

    RECRUITING

    Round Rock, Texas, 78681, United States

  • Cenexel CNS

    RECRUITING

    Los Alamitos, California, 90720, United States

  • Center for Advanced Research and Education

    RECRUITING

    Gainesville, Georgia, 30501, United States

  • Charlottesville Medical Research

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Coastal Carolina Research Center_North Charleston

    RECRUITING

    North Charleston, South Carolina, 29405, United States

  • Consano Clinical Research, LLC

    RECRUITING

    Shavano Park, Texas, 78231, United States

  • Cullman Clinical Trials

    RECRUITING

    Cullman, Alabama, 35055, United States

  • Diablo Clinical Research - Flourish Research

    RECRUITING

    Walnut Creek, California, 94598, United States

  • East-West Medical Research Institute

    RECRUITING

    Honolulu, Hawaii, 96814, United States

  • Endeavor Clinical Trials

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Flourish Research - San Antonio Medical Trials

    RECRUITING

    San Antonio, Texas, 78229, United States

  • K2 Medical Research The Villages

    RECRUITING

    The Villages, Florida, 32159, United States

  • L-MARC Research Center

    RECRUITING

    Louisville, Kentucky, 40213, United States

  • Lynn Health Science Institute

    RECRUITING

    Oklahoma City, Oklahoma, 73112, United States

  • Mercury Street Medical Group, PLLC

    RECRUITING

    Butte, Montana, 59701, United States

  • Ohio Clinical Trials

    RECRUITING

    Columbus, Ohio, 43212, United States

  • Palm Research Center, Mountainview Medical Center

    RECRUITING

    Las Vegas, Nevada, 89128, United States

  • Pinnacle Research Group

    RECRUITING

    Anniston, Alabama, 36207, United States

  • Precision Clinical Research

    RECRUITING

    Sunrise, Florida, 33351, United States

  • Rainier Clinical Research Center

    RECRUITING

    Renton, Washington, 98057, United States

  • Southwest General Healthcare Center

    RECRUITING

    Fort Myers, Florida, 33907, United States

  • Tampa Bay Medical Research

    RECRUITING

    Clearwater, Florida, 33761, United States

  • Tandem Clinical Research

    RECRUITING

    Marrero, Louisiana, 70072, United States

  • Tribe Clinical Research

    RECRUITING

    Greenville, South Carolina, 29607, United States

  • Valley Institute of Research, Rockwood Medical Clinic

    RECRUITING

    Fort Worth, Texas, 76164, United States

  • Velocity Clinical Research - Durham

    RECRUITING

    Durham, North Carolina, 27701, United States

  • Velocity Clinical Research - Omaha

    RECRUITING

    Omaha, Nebraska, 68134, United States

  • Velocity Clinical Research Dallas

    RECRUITING

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research, Medford

    RECRUITING

    Medford, Oregon, 97504, United States

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