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Warm IV fluid eases pain for emergency eye patients

NCT ID NCT07495449

Symptom relief Sponsor: Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The goal was to see if a simple warming device could make the treatment less painful and more comfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

142 people

The number who actually took part.

Started

Jan 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with acute ocular hypertension requiring intravenous mannitol treatment in the ophthalmology setting * Age 18 years or older * Conscious and able to communicate pain and comfort during infusion * Able to provide informed consent personally or via a legally authorized representative when appropriate * Able to complete study-related assessments during and shortly after mannitol infusion Exclusion Criteria: * Patients who did not require intravenous mannitol treatment * Known contraindication to intravenous mannitol treatment according to routine clinical practice * Patients receiving infusion of heat-sensitive fluids or medications for which infusion warming was not appropriate * Severe cognitive impairment, communication difficulty, or other conditions preventing reliable assessment of pain or comfort * Failure to complete key study outcome assessments * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

acute closed-angle glaucoma angle-closure glaucoma ocular hypertension primary angle-closure glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ocular hypertension glaucoma Intraocular hypertension Primary angle-closure glaucoma

Contacts and locations

Locations

  • Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong

    Shantou, Guangdong, 515041, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.