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Walking away from hypothyroidism fatigue: new study tests simple exercise fix

NCT ID NCT07205042

Symptom relief Sponsor: University of Karachi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a structured 12-week walking program can improve metabolism, reduce fatigue, and lower stress in women with hypothyroidism who are already on thyroid medication. 120 women aged 35-55 will either walk 30 minutes, 5 times a week under supervision, or continue their usual routine. Researchers will measure changes in basal metabolic rate, heart rate variability, and stress hormones.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
supervised walking program
What this could lead to
If it works, this could offer a simple, drug-free way to help women with hypothyroidism feel better and improve their metabolism.
What could go wrong
This is a small, early-stage trial with no blinding, so results may not be conclusive. The walking program requires commitment, and benefits may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 55 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged 35-55 years * Primary hypothyroidism with documented prior TSH \>4.5 mIU/L * Stable levothyroxine dose for at least 6 months * Sedentary lifestyle (\<150 minutes of moderate-vigorous activity per week) * BMI between 20-35 kg/m² * Able to walk unaided * Willing and able to provide written informed consent Exclusion Criteria: * Pregnant or lactating, or planning pregnancy during the study period * Use of beta-blockers, systemic corticosteroids, or medications significantly affecting heart rate, HRV, or metabolism * Uncontrolled hypertension, insulin-dependent diabetes, symptomatic cardiovascular disease, or orthopedic conditions limiting walking * Major psychiatric hospitalization in the past 12 months * Participation in another interventional trial within the past 30 days

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Conditions

The condition(s) this trial relates to.

hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypothyroidism

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Karachi

    Karachi, Sindh, 78500, Pakistan

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