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Vitamin c: the surprising new weapon against emergency room pain?

NCT ID NCT06306183

Symptom relief Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether vitamin C can reduce pain from recent muscle, bone, or joint injuries in emergency patients. Adults with moderate to severe pain are randomly given vitamin C or a placebo for three days. The goal is to see if this cheap, safe supplement can offer relief and cut down on opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin C (900 mg twice daily for 3 days)
What this could lead to
If it works, this could provide a simple, low-cost, and safe option to manage pain after injuries, reducing the need for opioids.
What could go wrong
This is a small, early-stage trial (204 participants) testing a short-term effect. Vitamin C may not reduce pain significantly, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 204 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years old 2. Presenting to the ED with acute MSK pain of ≤ 48 hours duration at triage 3. Verbal numerical rating scale pain intensity at triage of ≥ 4 on a 0-10 scale 4. Triaged to the ambulatory section of the ED 5. Able to communicate in French or English Exclusion Criteria: 1. Usage of Vit C supplements in the last week 2. Active cancer 3. Treated with opioids for any pain within 24 hours prior to recruitment 4. Treatment for chronic pain 5. Unable to fill out a pain intensity diary or unavailable for follow-up 6. Allergy to milk (lactose in the placebo) or Vit C 7. Treated with cyclosporine or warfarin 8. Pre-existing oxalate nephropathy, liver cirrhosis or hemochromatosis 9. Hospitalized after clinician evaluation

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Conditions

The condition(s) this trial relates to.

Acute Pain Emergencies Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, acute

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Québec - Université Laval

    NOT_YET_RECRUITING

    Québec, Quebec, Canada

  • Hopital du Sacre-Coeur de Montreal

    RECRUITING

    Montreal, Quebec, H4J 1C5, Canada

  • Hôtel-Dieu de Lévis

    NOT_YET_RECRUITING

    Lévis, Quebec, G6V 3Z1, Canada

  • The Ottawa Hospital - General and Civic Campus

    NOT_YET_RECRUITING

    Ottawa, Ontario, K1Y 1J8, Canada

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