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New ventilator coaching aims to shield lungs during recovery

NCT ID NCT07294768

Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new way of using mechanical ventilators, called VentCoach, to better protect the lungs of ICU patients with breathing failure. 18 adults on ventilators were randomly assigned to either the VentCoach protocol or standard care. The main goal was to see if doctors could follow the new protocol correctly, not to measure patient recovery. This is an early feasibility study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
VentCoach protocol (mechanical ventilation adjustment method)
What this could lead to
If successful, this could lead to a better way to set ventilators that reduces lung injury in critically ill patients.
What could go wrong
This is a very small feasibility study (18 people) testing only whether the protocol can be followed, not whether it improves outcomes. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Oct 2023

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with acute hypoxemic and/or hypercapnic respiratory failure. * Patients requiring intubation and mechanical ventilation for more than 24 hours. * VentCoach protocol is specific to volume controlled continuous mandatory ventilation (S-CMV). * Patient who are admitted to RMH 10-3/10-4 and MB 6BGF ICUs. * Age greater than or equal to 18 years. * Patient's legal representative should be able to provide informed consent to the study. Any participant speaking any language will be offered participation. Exclusion Criteria: * Intubation and mechanical ventilation for airway protection in the setting of procedures/surgeries, e.g. interventional radiology, surgery, or endoscopy. * Intubation and mechanical ventilation due to drug overdose with expected extubation of less than 24 hours. * Intubation and mechanical ventilation in the setting of cardiac arrest. * Intubation and mechanical ventilation for a primary neurological etiology, e.g. increased intracranial pressure, tumor mass effect, ischemic/hemorrhagic stroke, status epilepticus, etc. * Mechanical ventilation to be guided by esophageal balloon. * Subject deprived of freedom, minor, subject under a legal protective measure. * Change in end-of-life decision anticipated after enrollment (or estimated 6-month mortality rate of greater than 50%). Note: prone positioning is not a contraindication for participation.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation

Contacts and locations

Locations

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.