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Could a deep breath replace a clamp? new study tests Pain-Free biopsy

NCT ID NCT07496905

Symptom relief Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 19, 2026 · Updated 3 times

Summary

This study tests whether a simple breathing technique called the Valsalva maneuver can reduce pain during an endometrial biopsy, a procedure that samples the uterine lining. Normally, a clamp (tenaculum) is used to hold the cervix, which can cause pain. The Valsalva maneuver involves taking a deep breath and pushing, which may stabilize the uterus without the clamp. The trial will compare pain levels and procedure success in 120 women undergoing the biopsy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Valsalva maneuver
What this could lead to
If it works, this simple breathing technique could offer a less painful way to perform endometrial biopsies, reducing the need for instruments that cause discomfort.
What could go wrong
This is a small, early-stage trial with 120 participants, so results may not apply to everyone. The Valsalva maneuver may not reduce pain as effectively as hoped, and some women may still experience discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Jan 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: -Endometrial sampling indication in reproductive age group of patients over 18 years of age, who can communicate in Turkish. Exclusion Criteria: * Patients under 18 years of age - postmenopausal * Pregnancy * Patients with known stenotic cervical os * Patients with a history of acute cervicitis; * Patients with intense anxiety; * Need for simultaneous endocervical curettage; * Need for general or local anesthesia * Having used analgesic medication before the procedure; * History of a known malignancy, uterine anomaly, or leiomyoma affecting the cervical canal or uterine cavity, or uterine prolapse; * Patients with known chronic plevic pain

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Conditions

The condition(s) this trial relates to.

Metrorrhagia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abnormal uterine bleeding Pain in endometrial biopsy

Contacts and locations

Locations

  • Cemil Tascioglu City Hospital

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.