Scientists map hidden nerve wires to make epilepsy treatment safer
NCT ID NCT05664854
First seen Jun 06, 2026 · Last updated Jun 21, 2026 · Updated 4 times
Summary
This study aims to create a detailed map of the vagus nerve's internal wiring during routine epilepsy surgery. Researchers will use special electrode cuffs to stimulate different parts of the nerve and record which organs respond, while also taking quick electrical images. The goal is to understand how to stimulate only the right nerve bundles to treat epilepsy without causing side effects like voice changes or heart problems. Fifty adults already scheduled for vagus nerve stimulator implantation will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Hospital of Neurology and Neurosurgery
RECRUITINGLondon, Greater London, WC1N 3BG, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nerve cuff electrodes for stimulation and imaging
What this could lead to
If successful, this could lead to more precise vagus nerve stimulation with fewer side effects for conditions like epilepsy.
What could go wrong
This is a very early, small study (50 people) focused on mapping, not treatment. It may not lead to better devices or outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.