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Twin pregnancy mystery: could vaginal microbes predict early delivery?

NCT ID NCT06053697

Knowledge-focused Sponsor: University of Liverpool Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study looks at the tiny organisms living in the vagina of women pregnant with twins to see if they are linked to preterm birth. Researchers will take swabs and blood samples from 120 women at different points in pregnancy. The goal is to find clues that could one day help predict and prevent early delivery in twin pregnancies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify which women with twin pregnancies are at risk of preterm birth and point toward new ways to prevent it.
What could go wrong
This is an early observational study with only 120 participants, so results may not apply to all twin pregnancies. It looks for clues, not treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2022

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All monochorionic and dichorionic pregnancies at the Liverpool Women's Multiple Pregnancy Clinic will be approached for participation. This is a tertiary clinic caring for multiple pregnancies within Liverpool and the north west of England.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Twin pregnancy * Able to provide informed consent Exclusion Criteria: * Known or suspected severe structural/chromosomal fetal abnormality * Non-English speaking

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Conditions

The condition(s) this trial relates to.

Obstetric Labor, Premature pregnancy disorder Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical stiffness Multiple; pregnancy, complicated Preterm birth Preterm labor Twin dichorionic diamniotic placenta Twin monochorionic monoamniotic placenta Twin; pregnancy, affecting fetus or newborn Vaginal microbiome

Contacts and locations

Locations

  • Liverpool Women's NHS Foundation Trust

    Liverpool, Merseyside, L8 7SS, United Kingdom

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