University Of Liverpool

This study tests whether a single infusion of infliximab, a drug used for arthritis and Crohn's disease, can reduce inflammation in adults with acute pancreatitis. About 290 participants will receive either a low dose, a high dose, or a placebo. The main goal is to see if inflixi…

This study tests several potential COVID-19 treatments in adults to find safe doses and see if they help patients recover faster. It uses a flexible 'platform' design to add new drugs quickly. The trial includes people with mild to severe COVID-19 and focuses on reducing symptoms…

This study looks at how the HIV drug doravirine works in pregnant women. Researchers want to find the right dose to keep the virus under control and protect the baby. About 76 pregnant women with HIV will take either doravirine or standard HIV medication starting in the second tr…

This study tests a wearable robotic arm exoskeleton to help people with spinal cord injuries improve arm and hand function. Nine tetraplegic inpatients will use the device for 12 weeks alongside standard rehab. Researchers will measure changes in arm strength, movement, and daily…

This study checks whether lab tests that measure drug levels in body fluids are accurate and reliable. Researchers will collect blood, urine, and other samples from 100 adults who are taking certain medicines (like antibiotics, antivirals, birth control, or erectile dysfunction d…

This study looks at whether people with a torn ACL have weakness in the soleus, a calf muscle that helps protect the knee. Researchers will test leg strength in 55 participants with ACL tears and compare them to healthy individuals. The goal is to better understand muscle changes…

This study compares fat storage around the heart and liver in people with HIV versus the general population using MRI scans. Researchers aim to understand why HIV-positive individuals have double the risk of heart attacks. The study involves 100 participants aged 40 and older wit…

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-…