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Can upadacitinib sustain remission in Crohn's disease?

NCT ID NCT02782663

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study is testing whether upadacitinib, an oral medication, can safely and effectively manage Crohn's disease over the long term. Participants who completed a previous year-long study will continue taking the drug and be monitored for up to a year. The goal is to see if the drug helps maintain or achieve remission of the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
upadacitinib (also known as RINVOQ), an oral tablet
What this could lead to
If successful, this could support upadacitinib as a long-term treatment option for Crohn's disease, potentially improving remission rates and quality of life.
What could go wrong
This is a phase 2 open-label extension, meaning results are preliminary and may not confirm long-term benefits. Risks include potential side effects and the possibility that the drug may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

107 people

The number who actually took part.

Started

May 2016

Finished

Jul 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must have completed Study M13-740 through Week 52. * If female, participant must be postmenopausal, surgically sterile or on using a birth control method. Exclusion Criteria: * For any reason participant is considered by the investigator to be an unsuitable candidate * Female participant with a positive pregnancy test at Baseline or who is considering becoming pregnant during the study. * Participant is not in compliance with prior and concomitant medication requirements and procedures throughout Study M13-740.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crohn's disease (CD)

Contacts and locations

Locations

  • Amsterdam UMC, locatie AMC /ID# 149932

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Aspen Clinical Research /ID# 150020

    Orem, Utah, 84058, United States

  • CHRU Lille - Hopital Claude Huriez /ID# 149897

    Lille, Nord, 59037, France

  • Cabinet Particular Policlinic Algomed /ID# 149993

    Timișoara, 300002, Romania

  • Charm City Research Group /ID# 150040

    Towson, Maryland, 21204, United States

  • Clin Res Inst of Michigan, LLC /ID# 150008

    Chesterfield, Michigan, 48047, United States

  • Cotton O'Neil Clinical Research Center, Digestive Health /ID# 149900

    Topeka, Kansas, 66606, United States

  • DRK Kliniken Berlin Westend /ID# 149905

    Berlin, 14050, Germany

  • Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 149871

    Montreal, Quebec, H4A 3J1, Canada

  • Dunedin Hospital /ID# 149964

    Otago, Otago, 9016, New Zealand

  • Duplicate_(G.I.R.I.) GI Research Institute Foundation /ID# 149878

    Vancouver, British Columbia, V6Z 2K5, Canada

  • Duplicate_Aarhus University Hospital /ID# 149919

    Aarhus N, Central Jutland, 8200, Denmark

  • Duplicate_CHRU Nancy - Hopitaux de Brabois /ID# 149896

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France

  • Duplicate_CHU Amiens-Picardie Site Sud /ID# 149921

    Amiens, Somme, 80054, France

  • Duplicate_CHU de Liege /ID# 149912

    Liège, Liege, 4000, Belgium

  • Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 149958

    Bologna, Emilia-Romagna, 40138, Italy

  • Duplicate_KM Management, spol. s.r.o. /ID# 149949

    Nitra, Nitra Region, 949 01, Slovakia

  • Duplicate_Manchester University NHS Foundation Trust /ID# 150006

    Manchester, Manchester, M13 9WL, United Kingdom

  • Duplicate_University of Florida - Archer /ID# 150033

    Gainesville, Florida, 32610, United States

  • Duplicate_University of Louisville /ID# 149884

    Louisville, Kentucky, 40202, United States

  • GI Specialists of GA, PC /ID# 150015

    Marietta, Georgia, 30060, United States

  • Gastro I., s.r.o. /ID# 149948

    Prešov, Presov, 080 01, Slovakia

  • Gastroenterology Associates of Central Georgia, LLC /ID# 149870

    Macon, Georgia, 31201, United States

  • Hepato-Gastroenterologie HK, s.r.o. /ID# 149882

    Hradec Králové, Hradec Kralove, 500 12, Czechia

  • Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 149996

    Ferrol, A Coruna, 15405, Spain

  • Hospital Universitario La Paz /ID# 149997

    Madrid, Madrid, 28046, Spain

  • Investigative Clinical Research /ID# 149886

    Annapolis, Maryland, 21401, United States

  • Kansas City Research Institute /ID# 149888

    Kansas City, Missouri, 64131, United States

  • Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 149890

    Hvidovre, Capital Region, 2650, Denmark

  • Lovisenberg Diakonale Sykehus /ID# 149967

    Oslo, Oslo, 0440, Norway

  • Magyar Elhizastudomanyi Kozpont Kft. /ID# 149907

    Budapest, 1124, Hungary

  • Mayo Clinic - Rochester /ID# 149894

    Rochester, Minnesota, 55905-0001, United States

  • Medizinisches Versorgungszentrum Portal 10 /ID# 149930

    Münster, 48155, Germany

  • NYU Langone Long Island Clinical Research Associates /ID# 149976

    Lake Success, New York, 11042, United States

  • Nature Coast Clinical Research - Inverness /ID# 149975

    Inverness, Florida, 34452-4717, United States

  • Options Health Research, LLC /ID# 150010

    Tulsa, Oklahoma, 74104, United States

  • Oxford University Hospitals NHS Foundation Trust /ID# 149963

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

  • Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 149978

    Warsaw, Masovian Voivodeship, 02-507, Poland

  • Rabin Medical Center. /ID# 149942

    Petah Tikva, 4941492, Israel

  • Santa Sp. z o.o. Santa Familia Centrum Badan, Profilaktyki i Leczenia /ID# 149979

    Lodz, Łódź Voivodeship, 90-302, Poland

  • Texas Digestive Disease Consultants - Southlake /ID# 149869

    Southlake, Texas, 76092, United States

  • Texas Digestive Disease Consultants - Southlake /ID# 149989

    Southlake, Texas, 76092, United States

  • The Chaim Sheba Medical Center /ID# 149945

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The Ctr for Gastro Disorders /ID# 150012

    Hollywood, Florida, 33021, United States

  • Toronto Digestive Disease Associates /ID# 149877

    Vaughan, Ontario, L4L 4Y7, Canada

  • UC San Diego Health System /ID# 150041

    La Jolla, California, 92037, United States

  • Univ California, San Francisco /ID# 149987

    San Francisco, California, 94143-2204, United States

  • Univ NC Chapel Hill /ID# 149982

    Chapel Hill, North Carolina, 27514-4220, United States

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 149936

    Kiel, Schleswig-Holstein, 24105, Germany

  • Universitair Medisch Centrum Utrecht /ID# 149933

    Utrecht, Utrecht, 3584 CX, Netherlands

  • University Of Cincinnati Medical Center /ID# 149977

    Cincinnati, Ohio, 45219, United States

  • University of Alberta Hospital /ID# 149873

    Edmonton, Alberta, T6G 2B7, Canada

  • University of British Columbia (UBC) - Gordon and Leslie Diamond Health Care Ce /ID# 149876

    Vancouver, British Columbia, V5Z 1M9, Canada

  • University of Catanzaro /ID# 149927

    Catanzaro, Calabria, 88100, Italy

  • University of Virginia /ID# 149881

    Charlottesville, Virginia, 22908, United States

  • University of Washington /ID# 149988

    Seattle, Washington, 98109, United States

  • Virginia Mason Hospital & Medical Center /ID# 150042

    Seattle, Washington, 98101, United States

  • Washington University-School of Medicine /ID# 149899

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medicine/NYP /ID# 149895

    New York, New York, 10021-4872, United States

  • Wisconsin Center for Advanced Research /ID# 149863

    Milwaukee, Wisconsin, 53215, United States

  • Yitzhak Shamir Medical Center /ID# 149943

    Ẕerifin, Central District, 70300, Israel

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