Underwater colonoscopy technique could make polyp removal safer and faster
NCT ID NCT07490574
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involved 295 adults across multiple hospitals in Italy. The goal was to see if UESD is as good as the standard gas-assisted method for removing the entire growth in one piece, and whether it reduces complications and procedure time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Underwater endoscopic submucosal dissection (UESD) procedure
- What this could lead to
- If successful, this could offer a safer, faster, and more effective way to remove precancerous colorectal growths without surgery.
- What could go wrong
- This is a completed trial comparing two procedures, so results are known. However, the underwater method may not work for all lesion types or locations, and it requires specialized training.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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295 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adults aged 19 years or older Colorectal neoplastic lesion referred for endoscopic submucosal dissection Lesion considered amenable to en bloc endoscopic resection by ESD according to expert pre-procedural endoscopic assessment Written informed consent provided Exclusion Criteria: Known or suspected deep invasive neoplasia Inflammatory bowel disease Uninterrupted antithrombotic therapy Known coagulopathy Any clinical or lesion-related condition considered unsuitable for colorectal ESD by the treating endoscopist
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Campus Bio Medico Hospital
Rome, RM, 00100, Italy
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