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New enzyme pill may ease root canal pain

NCT ID NCT07239505

Symptom relief Sponsor: Fayoum University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment. 182 men with moderate to severe tooth pain will receive either Trinase or a placebo 30 minutes before the procedure. Pain levels and the need for extra painkillers will be tracked for 48 hours after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 182 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy male patients (ASA I or II) * Aged 18 to 50 years * Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar * Preoperative moderate to severe pain (VAS ≥45 mm) * Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I) Exclusion Criteria: Medically compromised patients (ASA III or higher) * History of allergy or intolerance to Trinase or any of its components (trypsin, bromelain, rutin) * Vertical root fracture * External or internal root resorption * Periodontal pocket depth \>5 mm * Tooth mobility Grade II or III * Presence of periapical lesion (radiolucency) * Female patients (to standardize pain perception and hormonal factors)

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Conditions

The condition(s) this trial relates to.

dental pulp disorder Pain, Postoperative pulpitis Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental pain Endodontic disease Postoperative pain after endodontic treatment Symptomatic irreversible pulpitis (SIP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fayoum University

    RECRUITING

    Al Fayyum, Faiyum Governorate, 12311, Egypt

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