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Can fasting or quitting smoking rewind your biological clock?

NCT ID NCT05678426

Knowledge-focused Sponsor: Universitaet Innsbruck Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether intermittent fasting or quitting smoking can change DNA markers linked to aging and cancer risk. 156 healthy women aged 30-60 followed a 6-month program with coaching and optional exercise. Researchers measured changes in DNA methylation patterns to see if these lifestyle shifts could lower disease risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

156 people

The number who actually took part.

Started

Apr 2021

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Women aged 30 to 60 2. Motivated to change their lifestyle Smoking cessation intervention: 3a. Smoking cessation: ≥10 cigarettes per day for at least the last five years Dietary intervention: 3b Dietary intervention: BMI between 25 and 35 NB \[Nota Bene\], should 3a and 3b apply, participant will be allocated to the smoking cessation intervention. Exclusion Criteria: 1. Relevant underlying conditions: 1. Current or previous malignant tumour or cancer 2. Current or previous significant cardiovascular disorder \[participants with elevated blood pressure are allowed to participate as long as it is well controlled under their current medication\] 3. Current or previous metabolic disorder (e.g., diabetes type I or II) \[in the dietary intervention arm, participants with current hypothyroidism/Morbus Hashimoto will be excluded as the switch to intermittent fasting may require a adjustment of their medication\] 4. Current or previous psychiatric disorder (e.g., eating disorder, depression) 2. Current pregnancy or lactation period 3. Total hysterectomy 4. Known current or previous premalignant lesion of the cervix uteri (CIN2/3) 5. Concurrent participation in another interventional trial

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Conditions

The condition(s) this trial relates to.

Intermittent Fasting Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Healthy lifestyle Intermittent fasting Smoking cessation

Contacts and locations

Locations

  • European Translational Oncology Prevention and Screening Institute

    Hall in Tirol, Tyrol, 6060, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.