Time-Restricted eating shows promise for psoriasis inflammation
NCT ID NCT04728165
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 5 times
Summary
This pilot study tested whether time-restricted feeding (eating all daily calories between 8am and 2pm, then fasting for 18 hours) could reduce inflammation in men with mild to moderate psoriasis. 27 participants (including healthy volunteers) stayed at the clinic for 4.5 days, wore glucose monitors, and completed meal tests. The study measured changes in immune cell activity and other markers of inflammation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- time-restricted feeding (eating only between 8am and 2pm each day)
- What this could lead to
- If it works, this could point toward a simple dietary approach to help manage inflammation in psoriasis.
- What could go wrong
- This is a very small pilot study (27 people) that only looks at blood markers, not actual skin improvement. It may not lead to any practical treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
27 people
The number who actually took part.
- Started
-
Jun 2021
- Finished
-
Jul 2023
- Lead sponsor
-
A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Males between the ages of 18 and 70 with mild to moderate active psoriasis by PASI score for inclusion in psoriasis group Age (plus or minus 5 yrs) and BMI (plus or minus 5 kg/m2) matched control male subjects for inclusion in the control group. Ability to provide informed consent Willingness and ability to participate in study procedures
- Ages
-
18 to 80 years
- Sex
-
Male participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: Individuals must meet the inclusion criteria listed below in order to be eligible to participate in the study. * Males between the ages of 18 and 80 with mild to moderate active psoriasis by PASI score for inclusion in psoriasis group * Age (plus or minus 10 yrs) and BMI (plus or minus 5 kg/m\^2) matched control male subjects for inclusion in the control group. * Ability to provide informed consent * Willingness and ability to participate in study procedures EXCLUSION CRITERIA: * Severe psoriasis by PASI (Psoriasis Area and Severity Index) score \> 12 * Treatment with systemic biologic immune modifying agents within the last 2 months. * Currently on treatment for allergies or other inflammatory diseases. * Has taken Vitamin B or tryptophan supplementation within 2 weeks of participation. * Unwillingness/inability to provide informed consent. * Individuals with known history of type 1 and 2 diabetes mellitus or other metabolic conditions that would interfere with study parameters including chronic kidney disease, chronic liver disease, history of hypoglycemia * On treatment with medication that would interfere with study parameters including anti-hyperglycemic medications, systemic steroids, adrenergic-stimulating agents, other medications known to affect sleep, circadian rhythms or metabolism. * Caffeine in excess of three 8 oz cups per day. * Factors that affect circadian rhythm including individuals who perform overnight shift work, irregular sleep and/ or eating schedules, regularly fast for more than 15 hours/ day * Regular use of tobacco product within last 3 months. * Consuming more than 3 servings of alcohol/ day * Engaged in competitive sports training * Moderate to severe claustrophobia * Unstable weight with more than 5% body weight change in last 3 months * Food allergies or intolerances or dietary patterns that would prohibit consumption of the metabolic diet or mixed meal test.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Psoriasis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gentler Heart-Lung machine may mean less Post-Surgery inflammation
- Can a Once-Daily moisturizer help psoriasis skin? patients put it to the test
- Can a fruit acid in tiny carriers rival steroid creams for psoriasis?
- Can a spoonful of yoghurt calm the Body's fire in the ICU?
- Vitamin B3 supplement put to the test against psoriasis inflammation
- Can monthly selfies and symptom logs reveal how chronic skin diseases flare and settle?