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Can a spoonful of yoghurt calm the Body's fire in the ICU?

NCT ID NCT07812415

Symptom relief Sponsor: All India Institute of Medical Sciences, Bhubaneswar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

This pilot trial asks whether adding plain yoghurt to standard tube feeding is safe and practical for adults who are critically ill in the intensive care unit. Twelve patients receive either yoghurt or usual care for three days. Researchers track inflammation markers and changes in gut bacteria to see if yoghurt shows early signs of helping.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
plain yoghurt given through a feeding tube
What this could lead to
If yoghurt helps, it could offer a simple, low-cost way to calm inflammation and support gut bacteria in people who are critically ill and fed through a tube.
What could go wrong
This is a tiny pilot study of 12 people, so any inflammation or microbiome changes may be chance or may not hold in a larger group. Yoghurt can cause digestive upset or allergic reactions in people sensitive to dairy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Jun 2021

Finished

Aug 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-65 years Admitted to Intensive Care Unit (ICU) with critical illness requiring nasogastric feeding Expected to remain in ICU for at least 3 days Able to receive enteral nutrition via nasogastric tube Exclusion Criteria: * Known allergy or intolerance to dairy products Pre-existing gastrointestinal disorders (e.g., inflammatory bowel disease, short bowel syndrome) Severe liver disease or renal failure requiring dialysis Immunocompromised state (e.g., HIV/AIDS, chemotherapy) Participation in another interventional clinical trial within the past 30 days

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Systemic inflammation

Contacts and locations

Locations

  • All India Institute of Medical Sciences (AIIMS) Bhubaneswar

    Bhubaneswar, Odisha, 751019, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.