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Can eating only during certain hours help aging brains? small study tests the idea

NCT ID NCT05997316

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a time-restricted eating plan (fasting for 16 hours, 2-3 days a week) is feasible and acceptable for older adults aged 65-80 who have mild cognitive impairment and obesity. 33 participants completed the 12-week program, working with a psychologist to gradually adopt the eating schedule. The researchers also measured changes in memory, thinking skills, and metabolic health, but the main goal was to see if people would stick with the plan.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
time-restricted eating (behavioral intervention)
What this could lead to
If successful, this could point toward a simple dietary strategy to support brain health in older adults at risk for dementia.
What could go wrong
This is a small, early feasibility study with only 33 participants. It was not designed to prove that time-restricted eating improves cognition, only that it is acceptable and doable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Aug 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Subjects will include those men and women: * aged 65-80 years, * with amnestic Mild Cognitive Impairment (Montreal Cognitive Assessment Battery score \[MoCA\] total score 19-25 or a phonemic fluency score of =\<12 (with MoCA \>25) or semantic fluency score of =\<15 (with MoCA \>15); and score of \> 1.0 on the Mail-in Cognitive Function Screening Instrument), * obese (body mass index 27.5-40 kg/m\^2), * sedentary, and * willing to participate in all aspects of the proposed intervention. Exclusion Criteria: Reasons for participant exclusion will include: * secondary causes of obesity, * evidence of clinical dementia (MoCA score \< 18), severe chronic kidney disease (eGFR \<45 ml/min/1.73m\^2), * heart failure, * high grade arrhythmias, * severe valvular heart disease, * severe asthma or chronic obstructive lung disease, * diabetes requiring insulin, * musculoskeletal or neurologic problems that would preclude participation in aerobic exercise training, * a major psychiatric disorder, * a history of drug abuse, * alcohol consumption \>14 drinks/week, * gastric bypass surgery, * non-English speaking, or * a life-limiting comorbid medical condition (e.g. cancer).

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment Obesity

Contacts and locations

Locations

  • University of North Carolina

    Chapel Hill, North Carolina, 27519, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.