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Testosterone 'Muscle Memory' may help aging men stay stronger longer

NCT ID NCT05964920

Knowledge-focused Sponsor: Norwegian School of Sport Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether giving older men testosterone for a few weeks, with or without resistance exercise, could create a lasting 'muscle memory' that makes it easier to regain muscle later. Forty-five sedentary men aged 55-70 received either testosterone or placebo injections, some also did supervised weight training. After a break, all men retrained to see if prior testosterone exposure boosted their results. The goal is to understand if a short hormone boost can have long-term benefits for muscle health in aging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Testosterone undecanoate (Nebido) injections
What this could lead to
If it works, this could point toward a way to help older men maintain muscle strength and function more easily after a short course of testosterone.
What could go wrong
This is a small, early-stage study (45 men) focused on understanding mechanisms, not proving a treatment. Results may not apply to women or younger people, and testosterone carries risks like hormonal side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

45 people

The number who actually took part.

Started

Sep 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 70 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sedentary males * 55-70 years old * Serum testosterone levels \>8 nmol/L measured in the morning * Without any known illness, disease or other conditions * Undergone screening through medical questionnaire, physical examination, routine blood tests and urine sample * Written informed consent received Exclusion Criteria: * Current or previous participation in a formal exercise regime * A BMI \< 18 or \> 30 kg·m2 * Hypersensitivity to the study drug or to any of its constituents * Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100 mmHg), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event * Family history of early (\<55y) death from cardiovascular disease * Haematocrit \>50% * Malignancy * Prostate-specific antigen (PSA) \>4 ng/mL * Lower urinary tract symptoms * Taking beta-adrenergic blocking agents, statins, non-steroidal anti-inflammatory drugs * Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial), epilepsy * Respiratory diseases including: pulmonary hypertension, chronic obstructive pulmanary disease (COPD), asthma, sleep apnoea * Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, type 1 or 2 diabetes * Active inflammatory bowel or renal disease * Current or previous steroid treatment or hormone replacement therapy * Clotting dysfunction * Musculoskeletal or neurological disorders * Alcohol or drug abuse * Receiving oral anticoagulants * Serum testosterone levels above the reference range for 50 year olds (\>32 nmol/L) (Bjerner et al., 2009) measured in the morning 1

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Conditions

The condition(s) this trial relates to.

hypogonadism hypogonadism, male

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Age-related sarcopenia Healthy aging Testosterone deficiency

Contacts and locations

Locations

  • Norwegian School of Sport Sciences

    Oslo, Oslo, 0863, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.