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TENS for MS: scientists peek inside the brain to see if it works

NCT ID NCT06432686

Knowledge-focused Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This pilot study will use brain scans (fMRI) to understand how transcutaneous electrical nerve stimulation (TENS) affects brain activity in 30 people with multiple sclerosis (MS). TENS is a safe, home-use device that sends mild electrical pulses through the skin. The goal is to learn why TENS might reduce fatigue and walking problems, not yet to prove it works as a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous Electrical Nerve Stimulation (TENS)
What this could lead to
If successful, this study could clarify how TENS works in the brain, paving the way for larger trials to test it as a home-based treatment for MS-related fatigue and walking difficulty.
What could go wrong
This is a very small pilot study (30 people) focused on brain imaging, not on proving TENS actually improves symptoms. The results may not translate into real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age: 18-65 years * EDSS score \< 7 Exclusion Criteria: * metal or electrical implants * BMI \> 40 * claustrophobia * being pregnant * having a psychiatric disorder * having cognitive or communication problems which reduces the capacity to understand instructions * having a neurological disorder other than MS * having cardiac arrhythmia

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Conditions

The condition(s) this trial relates to.

Fatigue Mobility Limitation multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fatigue Multiple sclerosis Walking, difficulty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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