Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Zapping the brain from outside the skull: a new hope for Drug-Resistant epilepsy?

NCT ID NCT07764718

Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether a non-invasive technique called temporal interference (TI) stimulation can reduce abnormal electrical activity in the brains of adults with drug-resistant focal epilepsy. Participants, who are already undergoing brain monitoring with implanted electrodes for clinical care, will receive TI stimulation through scalp electrodes during wakefulness and, when possible, natural sleep. The study will measure changes in epilepsy-related brain signals and sleep rhythms, and compare TI with direct electrical stimulation delivered through the implanted electrodes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-invasive temporal interference electrical stimulation delivered through scalp electrodes, compared with direct electrical stimulation via implanted electrodes.
What this could lead to
If successful, this could point toward a non-invasive way to calm seizure-related brain activity and improve sleep rhythms in people with epilepsy, potentially offering an alternative to more invasive treatments.
What could go wrong
This is an early, small study focused on brain activity markers, not seizure reduction. The effects may not translate into real-world seizure control, and the stimulation may not be effective or comfortable for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients with focal DRE who will undergo presurgical evaluation with sEEG * Availability of at least one sEEG electrode inserted into the thalamus for clinical purposes * sEEG performed with the indication to identify one single epileptic focus * Ability to provide written informed consent and comply with the study protocol Exclusion Criteria: \- Remote resective/ablative brain surgery

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Drug-resistant focal epilepsy are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Drug-resistant focal epilepsy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.