Tiny brain probe aims to spy on seizures
NCT ID NCT05335187
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a special electrode that can record the activity of individual brain cells during epileptic seizures. Thirty adults with drug-resistant epilepsy who already need brain monitoring for surgery will have these electrodes implanted for a few weeks. The main goal is to see if the device is safe and can capture clear signals from single neurons.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- micro-macro electrode implantation
- What this could lead to
- If successful, this could help researchers better understand how seizures start and spread in the brain, potentially guiding future treatments.
- What could go wrong
- This is a small, early-stage safety study with only 30 participants. The device may cause side effects or fail to record enough neurons, and the findings may not lead to direct patient benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient 18 years old or older suffering from drug-resistant focal epilepsy. * Candidate for epilepsy surgery. * Requires evaluation with intracranial stereo-EEG electrodes. * Able and willing to provide informed consent. Exclusion Criteria: * Any acute infection (e.g. fever, throat infection). * Skin or scalp infection over the implantation site. * Thin or fragile skull bones, which would prevent stereo-EEG electrodes from being anchored safely. * Increased risk of infections, either from a medical condition or from immunosuppressant medication. * Increased risk of bleeding, either from a medical condition or from antiplatelet or anticoagulant medication. * Severe concomitant medical disease (including, but not limited to, cardiovascular, respiratory, renal or hepatic disease). * Severe concomitant psychiatric disease or major psychological distress. * Women who are pregnant or breastfeeding during the study. * Patients who have an implanted stimulation device (e.g. pacemaker, defibrillator, neurostimulator).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hôpitaux Universitaires de Genève
RECRUITINGGeneva, CH, 1205, Switzerland
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Inselspital Bern
RECRUITINGBern, Canton of Bern, 3010, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Reading the Brain's signals to predict who benefits from deep brain stimulation
- Can a Comfort-Focused education program improve life with epilepsy?
- Can video games rewire young brains after injury?
- High-Fat Diet's effect on epilepsy: scientists track brain signals
- Brain implant that fires at seizures tested in teens